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Nup43 Nucleoporin 43kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42209, updated on 28-Oct-2024

Summary

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Official Symbol
Nup43provided by FlyBase
Official Full Name
Nucleoporin 43kDprovided by FlyBase
Primary source
FLYBASE:FBgn0038609
Locus tag
Dmel_CG7671
See related
AllianceGenome:FB:FBgn0038609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7671; Dmel\CG7671; nup43
Summary
Involved in mitotic cell cycle. Predicted to be part of nuclear pore outer ring. Is expressed in organism. Used to study candidiasis. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See Nup43 in Genome Data Viewer
Location:
91A3-91A3; 3-63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18366638..18367913)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14192360..14193635)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45634 Neighboring gene hemingway Neighboring gene WRN exonuclease Neighboring gene glass Neighboring gene long non-coding RNA:CR14310

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of Bub3 and Nup75 in the Drosophila male germline lineage. Yildirim K, et al. Cells Dev, 2023 Sep. PMID 37286104
  2. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Anderson EN, et al. Elife, 2021 May 26. PMID 34060470, Free PMC Article
  3. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Lin YC, et al. Nat Neurosci, 2021 Aug. PMID 34059832, Free PMC Article
  4. Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins. Katsani KR, et al. Sci Rep, 2014 Apr 11. PMID 24722254, Free PMC Article
  5. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle HMP PubMed 
Component Evidence Code Pubs
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore outer ring ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleoporin 43kD
Names
CG7671-PA
Nup43-PA
nucleoporin 43

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18366638..18367913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142459.4 → NP_650716.2  nucleoporin 43kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650716.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJQ1, Q9VE85
    Related
    FBpp0082998
    Conserved Domains (3) summary
    COG2319
    Location:142 → 344
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:16 → 73
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:74 → 347
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYC6 Q8SYC6
Q9VE85 Q9VE85

Gene LinkOut

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