U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alg1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42146, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Alg1provided by FlyBase
Official Full Name
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038552
Locus tag
Dmel_CG18012
See related
AllianceGenome:FB:FBgn0038552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18012; dAlg1; Dmel\CG18012
Summary
Predicted to enable chitobiosyldiphosphodolichol beta-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Alg1 in Genome Data Viewer
Location:
90C6-90C6; 3-61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17809401..17811134, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13635123..13636848, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Oddjob Neighboring gene tincar Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning. Sung HH, et al. Nat Commun, 2024 Aug 27. PMID 39191750, Free PMC Article
  2. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953
  3. A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Fu Y, et al. Hum Mol Genet, 2017 Feb 15. PMID 28164240, Free PMC Article
  4. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  5. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
Names
Alg1-PA
B-1,4-mannosyltransferase
CG18012-PA
NP_650662.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17809401..17811134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142405.3 → NP_650662.1  ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650662.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEE9
    Related
    FBpp0082947
    Conserved Domains (2) summary
    cd03816
    Location:6 → 442
    GT1_ALG1_like; This family is most closely related to the GT1 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and ...
    PLN02275
    Location:7 → 402
    PLN02275; transferase, transferring glycosyl groups
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEE9 Q9VEE9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous