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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Gallus gallus (chicken) ]

Gene ID: 420784, updated on 10-Oct-2024

Summary

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Symbol
EZH2provided by CGNC
Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by CGNC
Primary source
CGNC:9422
See related
Ensembl:ENSGALG00010008330
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See EZH2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (53956108..54005051, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (53890218..53939132, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417786 Neighboring gene contactin associated protein 2 Neighboring gene cullin 1 Neighboring gene uncharacterized LOC121109819 Neighboring gene protein disulfide isomerase family A member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21. Akizu N, et al. Open Biol, 2016 Apr. PMID 27248655, Free PMC Article
  2. MiR-138 inhibits EZH2 methyltransferase expression and methylation of histone H3 at lysine 27, and affects thermotolerance acquisition. Kisliouk T, et al. Eur J Neurosci, 2011 Jan. PMID 21070394

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EZH2-mediated repression of p21(WAF1/CIP1) contributes to disruption of the neuroepithelium (NE) structure, correlating with alteration of the Rho pathway, and reduces neural progenitor proliferation.
    Title: EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21.
  2. Results describe the inhibitory role of miR-138 in the regulation of EZH2 expression in thermoregulatory system development and functioning.
    Title: MiR-138 inhibits EZH2 methyltransferase expression and methylation of histone H3 at lysine 27, and affects thermotolerance acquisition.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K27 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
XP_004935118.1
XP_004935119.1
XP_015131394.1
XP_015131395.1
XP_015131396.1
XP_015131398.1
XP_025003367.1
XP_040520457.1
XP_040520458.1
XP_040520459.1
XP_040520460.1
XP_040520461.1
XP_040520462.1
XP_040520463.1
XP_040520464.1
XP_040520466.1
XP_040520467.1
XP_040552389.1
XP_040552390.1
XP_046768534.1
XP_046768535.1
XP_046768536.1
XP_046768537.1
XP_046789917.1
XP_046789926.1
XP_046789933.1
XP_046789938.1
XP_418879.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    53956108..54005051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046933982.1 → XP_046789938.1  histone-lysine N-methyltransferase EZH2 isoform X6

    Related
    ENSGALP00010011470.1, ENSGALT00010019922.1

  2. XM_015275912.4 → XP_015131398.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3, A0A8V0Y235
    Related
    ENSGALP00010011471.1, ENSGALT00010019923.1
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  3. XM_040696456.2 → XP_040552390.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y244
    Conserved Domains (4) summary
    cd19218
    Location:615 → 734
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:164 → 255
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:565 → 596
    preSET_CXC; CXC domain

  4. XM_015275910.4 → XP_015131396.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  5. XM_025147599.3 → XP_025003367.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y235
    Related
    ENSGALP00010011478.1, ENSGALT00010019930.1
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  6. XM_004935062.5 → XP_004935119.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3, A0A8V0Y235
    Related
    ENSGALP00010011475.1, ENSGALT00010019927.1
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  7. XM_004935061.5 → XP_004935118.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y244
    Related
    ENSGALP00010011481.1, ENSGALT00010019933.1
    Conserved Domains (4) summary
    cd19218
    Location:615 → 734
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:164 → 255
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:565 → 596
    preSET_CXC; CXC domain

  8. XM_418879.8 → XP_418879.3  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  9. XM_046933970.1 → XP_046789926.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y244

  10. XM_040696455.2 → XP_040552389.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  11. XM_015275909.4 → XP_015131395.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:629 → 748
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:68 → 97
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:178 → 269
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:579 → 610
    preSET_CXC; CXC domain

  12. XM_015275908.4 → XP_015131394.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y617
    Related
    ENSGALP00010011474.1, ENSGALT00010019926.1
    Conserved Domains (4) summary
    cd19218
    Location:638 → 757
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:68 → 97
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:187 → 278
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:588 → 619
    preSET_CXC; CXC domain

  13. XM_046933961.1 → XP_046789917.1  histone-lysine N-methyltransferase EZH2 isoform X3

  14. XM_046933977.1 → XP_046789933.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    53890218..53939132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046912581.1 → XP_046768537.1  histone-lysine N-methyltransferase EZH2 isoform X6

  2. XM_040664532.2 → XP_040520466.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3, A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  3. XM_040664529.2 → XP_040520463.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y244
    Conserved Domains (4) summary
    cd19218
    Location:615 → 734
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:164 → 255
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:565 → 596
    preSET_CXC; CXC domain

  4. XM_040664526.2 → XP_040520460.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  5. XM_040664533.2 → XP_040520467.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  6. XM_040664530.2 → XP_040520464.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3, A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  7. XM_040664528.2 → XP_040520462.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y244
    Conserved Domains (4) summary
    cd19218
    Location:615 → 734
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:164 → 255
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:565 → 596
    preSET_CXC; CXC domain

  8. XM_040664525.2 → XP_040520459.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  9. XM_046912579.1 → XP_046768535.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Y244

  10. XM_040664527.2 → XP_040520461.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:624 → 743
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:54 → 83
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:173 → 264
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:574 → 605
    preSET_CXC; CXC domain

  11. XM_040664524.2 → XP_040520458.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y235
    Conserved Domains (4) summary
    cd19218
    Location:629 → 748
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:68 → 97
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:178 → 269
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:579 → 610
    preSET_CXC; CXC domain

  12. XM_040664523.2 → XP_040520457.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y235, A0A8V0Y617
    Conserved Domains (4) summary
    cd19218
    Location:638 → 757
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:68 → 97
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:187 → 278
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:588 → 619
    preSET_CXC; CXC domain

  13. XM_046912578.1 → XP_046768534.1  histone-lysine N-methyltransferase EZH2 isoform X3

  14. XM_046912580.1 → XP_046768536.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0XZM3
Nucleotide Protein Strain
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