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MEF2A myocyte enhancer factor 2A [ Homo sapiens (human) ]

Gene ID: 4205, updated on 3-Apr-2024

Summary

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Official Symbol
MEF2Aprovided by HGNC
Official Full Name
myocyte enhancer factor 2Aprovided by HGNC
Primary source
HGNC:HGNC:6993
See related
Ensembl:ENSG00000068305 MIM:600660; AllianceGenome:HGNC:6993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mef2; ADCAD1; RSRFC4; RSRFC9
Summary
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q26.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (99565417..99716488)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (97329154..97480250)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (100105622..100256693)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100105511-100106486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100106487-100107460 Neighboring gene ribosomal protein L7 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100119332-100119832 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:100119833-100120333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10161 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:100169236-100169886 Neighboring gene MPRA-validated peak2449 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100266134-100266634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100266635-100267135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6874 Neighboring gene LysM domain containing 4 Neighboring gene MPRA-validated peak2450 silencer Neighboring gene uncharacterized LOC105371020 Neighboring gene RNA, 7SL, cytoplasmic 484, pseudogene Neighboring gene dynamin 1 pseudogene 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A PGE(2)-MEF2A axis enables context-dependent control of inflammatory gene expression. Cilenti F, et al. Immunity, 2021 Aug 10. PMID 34129840, Free PMC Article
  2. Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy. Qiao Q, et al. Clin Chem Lab Med, 2021 Apr 27. PMID 33554560
  3. Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway. Liu B, et al. Aging (Albany NY), 2019 Jun 10. PMID 31182679, Free PMC Article
  4. MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells. Xiong Y, et al. BMC Mol Biol, 2019 Mar 18. PMID 30885136, Free PMC Article
  5. Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface. Wei J, et al. JCI Insight, 2017 Sep 7. PMID 28878124, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
    Title: Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
  2. Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
    Title: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
  3. A Study of transcription factor MEF2A gene polymorphisms in patients with coronary artery disease.
    Title: A Study of transcription factor MEF2A gene polymorphisms in patients with coronary artery disease.
  4. Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population.
    Title: Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population.
  5. HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
    Title: HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation.
  6. MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A.
    Title: MiRNA-615-3p Alleviates Oxidative Stress Injury of Human Cardiomyocytes Via PI3K/Akt Signaling by Targeting MEF2A.
  7. Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy.
    Title: Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy.
  8. MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.
    Title: MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression.
  9. MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis.
    Title: MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis.
  10. A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression.
    Title: A PGE(2)-MEF2A axis enables context-dependent control of inflammatory gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Coronary artery disease, autosomal dominant, 1
MedGen: C1842247 OMIM: 608320 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
tat HIV-1 Tat increases levels of phosphorylated MEF2 in human neuronal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERK5 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitochondrial genome maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion distribution ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle organ development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cardiac muscle hypertrophy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ventricular cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myocyte-specific enhancer factor 2A
Names
MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
serum response factor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016443.2 RefSeqGene

    Range
    5057..155561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130926.5 → NP_001124398.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001124398.1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A8K720
    Related
    ENSP00000509537.1, ENST00000691492.1
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  2. NM_001130927.5 → NP_001124399.1  myocyte-specific enhancer factor 2A isoform 3

    See identical proteins and their annotated locations for NP_001124399.1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45363.1
    UniProtKB/TrEMBL
    A8K720
    Related
    ENSP00000454120.1, ENST00000558812.5
    Conserved Domains (2) summary
    pfam12347
    Location:29 → 82
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:2 → 25
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

  3. NM_001130928.4 → NP_001124400.1  myocyte-specific enhancer factor 2A isoform 4

    See identical proteins and their annotated locations for NP_001124400.1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS58401.1
    UniProtKB/TrEMBL
    A0A0S2Z4C8, A8K720
    Related
    ENSP00000399460.2, ENST00000449277.6
    Conserved Domains (2) summary
    pfam12347
    Location:29 → 81
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:2 → 25
    MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

  4. NM_001171894.5 → NP_001165365.1  myocyte-specific enhancer factor 2A isoform 2

    See identical proteins and their annotated locations for NP_001165365.1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A8K720
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  5. NM_001319206.4 → NP_001306135.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0, A8K720
    Related
    ENSP00000453095.1, ENST00000557942.6
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  6. NM_001352614.4 → NP_001339543.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A8K720
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  7. NM_001352615.4 → NP_001339544.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A8K720
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  8. NM_001352616.4 → NP_001339545.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  9. NM_001352617.4 → NP_001339546.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  10. NM_001352618.4 → NP_001339547.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    UniProtKB/TrEMBL
    A8K720
    Related
    ENSP00000508747.1, ENST00000685785.1
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  11. NM_001365201.3 → NP_001352130.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92068.1
    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Related
    ENSP00000337202.8, ENST00000338042.11
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  12. NM_001365202.3 → NP_001352131.1  myocyte-specific enhancer factor 2A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92068.1
    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Related
    ENSP00000509700.1, ENST00000690055.1
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  13. NM_001365203.3 → NP_001352132.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92067.1
    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453, A8K720
    Related
    ENSP00000509137.1, ENST00000686611.1
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  14. NM_001365204.3 → NP_001352133.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92067.1
    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  15. NM_001365205.3 → NP_001352134.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  16. NM_001365206.3 → NP_001352135.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    UniProtKB/TrEMBL
    A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  17. NM_001365207.3 → NP_001352136.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  18. NM_001365208.3 → NP_001352137.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417, A8K720
    Related
    ENSP00000453441.1, ENST00000557785.5
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  19. NM_001365209.3 → NP_001352138.1  myocyte-specific enhancer factor 2A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45363.1
    UniProtKB/TrEMBL
    A8K720
    Conserved Domains (2) summary
    pfam12347
    Location:29 → 82
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:2 → 25
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

  20. NM_001365210.2 → NP_001352139.1  myocyte-specific enhancer factor 2A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  21. NM_001365211.2 → NP_001352140.1  myocyte-specific enhancer factor 2A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  22. NM_001393558.2 → NP_001380487.1  myocyte-specific enhancer factor 2A isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    UniProtKB/TrEMBL
    A8K720
    Conserved Domains (1) summary
    pfam12347
    Location:29 → 83
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  23. NM_001393559.2 → NP_001380488.1  myocyte-specific enhancer factor 2A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS58401.1
    UniProtKB/TrEMBL
    A0A0S2Z4C8, A8K720
    Conserved Domains (2) summary
    pfam12347
    Location:29 → 81
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:2 → 25
    MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

  24. NM_001393560.2 → NP_001380489.1  myocyte-specific enhancer factor 2A isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (2) summary
    COG5068
    Location:1 → 309
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  25. NM_001393561.3 → NP_001380490.1  myocyte-specific enhancer factor 2A isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Conserved Domains (1) summary
    cl00109
    Location:2 → 20
    MADS; MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type ...

  26. NM_001400028.1 → NP_001386957.1  myocyte-specific enhancer factor 2A isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  27. NM_001400029.1 → NP_001386958.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92067.1
    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  28. NM_001400030.1 → NP_001386959.1  myocyte-specific enhancer factor 2A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS92067.1
    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  29. NM_001400031.1 → NP_001386960.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  30. NM_001400032.1 → NP_001386961.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  31. NM_001400033.1 → NP_001386962.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  32. NM_001400034.1 → NP_001386963.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  33. NM_001400035.1 → NP_001386964.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  34. NM_001400036.1 → NP_001386965.1  myocyte-specific enhancer factor 2A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS81920.1
    UniProtKB/TrEMBL
    A0A0S2Z4N0

  35. NM_001400037.1 → NP_001386966.1  myocyte-specific enhancer factor 2A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  36. NM_001400038.1 → NP_001386967.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  37. NM_001400039.1 → NP_001386968.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  38. NM_001400040.1 → NP_001386969.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  39. NM_001400049.1 → NP_001386978.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  40. NM_001400050.1 → NP_001386979.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  41. NM_001400051.1 → NP_001386980.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  42. NM_001400052.1 → NP_001386981.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  43. NM_001400053.1 → NP_001386982.1  myocyte-specific enhancer factor 2A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454

  44. NM_001400054.1 → NP_001386983.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  45. NM_001400055.1 → NP_001386984.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  46. NM_001400056.1 → NP_001386985.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  47. NM_001400057.1 → NP_001386986.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  48. NM_001400058.1 → NP_001386987.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  49. NM_001400059.1 → NP_001386988.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  50. NM_001400060.1 → NP_001386989.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  51. NM_001400061.1 → NP_001386990.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  52. NM_001400062.1 → NP_001386991.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  53. NM_001400063.1 → NP_001386992.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  54. NM_001400064.1 → NP_001386993.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  55. NM_001400065.1 → NP_001386994.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  56. NM_001400066.1 → NP_001386995.1  myocyte-specific enhancer factor 2A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS53978.1
    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  57. NM_001400067.1 → NP_001386996.1  myocyte-specific enhancer factor 2A isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  58. NM_001400068.1 → NP_001386997.1  myocyte-specific enhancer factor 2A isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  59. NM_001400069.1 → NP_001386998.1  myocyte-specific enhancer factor 2A isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  60. NM_001400070.1 → NP_001386999.1  myocyte-specific enhancer factor 2A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  61. NM_001400071.1 → NP_001387000.1  myocyte-specific enhancer factor 2A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967

  62. NM_005587.6 → NP_005578.2  myocyte-specific enhancer factor 2A isoform 1

    See identical proteins and their annotated locations for NP_005578.2

    Status: REVIEWED

    Source sequence(s)
    AC022692, AC103967
    Consensus CDS
    CCDS45362.1
    UniProtKB/TrEMBL
    A0A0S2Z454, A8K720
    Related
    ENSP00000346389.5, ENST00000354410.9
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    99565417..99716488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521572.3 → XP_011519874.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519874.1

    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  2. XM_011521579.3 → XP_011519881.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519881.1

    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  3. XM_047432530.1 → XP_047288486.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  4. XM_047432531.1 → XP_047288487.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  5. XM_047432528.1 → XP_047288484.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454

  6. XM_011521582.3 → XP_011519884.1  myocyte-specific enhancer factor 2A isoform X2

    See identical proteins and their annotated locations for XP_011519884.1

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  7. XM_047432520.1 → XP_047288476.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  8. XM_047432523.1 → XP_047288479.1  myocyte-specific enhancer factor 2A isoform X4

  9. XM_047432521.1 → XP_047288477.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  10. XM_047432529.1 → XP_047288485.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454

  11. XM_011521585.3 → XP_011519887.1  myocyte-specific enhancer factor 2A isoform X7

    UniProtKB/TrEMBL
    A8K720
    Conserved Domains (2) summary
    pfam12347
    Location:30 → 88
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:2 → 18
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...

  12. XM_047432532.1 → XP_047288488.1  myocyte-specific enhancer factor 2A isoform X8

  13. XM_011521573.3 → XP_011519875.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519875.1

    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  14. XM_047432527.1 → XP_047288483.1  myocyte-specific enhancer factor 2A isoform X4

  15. XM_047432519.1 → XP_047288475.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  16. XM_047432526.1 → XP_047288482.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  17. XM_047432522.1 → XP_047288478.1  myocyte-specific enhancer factor 2A isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4N0

  18. XM_047432525.1 → XP_047288481.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417
    Conserved Domains (2) summary
    COG5068
    Location:1 → 235
    ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

  19. XM_011521577.3 → XP_011519879.1  myocyte-specific enhancer factor 2A isoform X1

    See identical proteins and their annotated locations for XP_011519879.1

    UniProtKB/TrEMBL
    A0A8I5KVQ4, A8K720
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 156
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  20. XM_047432524.1 → XP_047288480.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    97329154..97480250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377935.1 → XP_054233910.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  2. XM_054377938.1 → XP_054233913.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  3. XM_054377951.1 → XP_054233926.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417

  4. XM_054377952.1 → XP_054233927.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417

  5. XM_054377949.1 → XP_054233924.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454

  6. XM_054377941.1 → XP_054233916.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  7. XM_054377940.1 → XP_054233915.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  8. XM_054377944.1 → XP_054233919.1  myocyte-specific enhancer factor 2A isoform X4

  9. XM_054377942.1 → XP_054233917.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  10. XM_054377950.1 → XP_054233925.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454

  11. XM_054377953.1 → XP_054233928.1  myocyte-specific enhancer factor 2A isoform X7

  12. XM_054377954.1 → XP_054233929.1  myocyte-specific enhancer factor 2A isoform X8

  13. XM_054377936.1 → XP_054233911.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  14. XM_054377948.1 → XP_054233923.1  myocyte-specific enhancer factor 2A isoform X4

  15. XM_054377939.1 → XP_054233914.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  16. XM_054377947.1 → XP_054233922.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/Swiss-Prot
    B4DFQ7, F6XG23, O43814, Q02078, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14
    UniProtKB/TrEMBL
    A0A0S2Z453

  17. XM_054377943.1 → XP_054233918.1  myocyte-specific enhancer factor 2A isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4N0

  18. XM_054377946.1 → XP_054233921.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z417

  19. XM_054377937.1 → XP_054233912.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVQ4

  20. XM_054377945.1 → XP_054233920.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A0S2Z454
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02078.1 GenPept UniProtKB/Swiss-Prot:Q02078

Gene LinkOut

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