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AhcyL2 Adenosylhomocysteinase like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42043, updated on 2-Nov-2024

Summary

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Official Symbol
AhcyL2provided by FlyBase
Official Full Name
Adenosylhomocysteinase like 2provided by FlyBase
Primary source
FLYBASE:FBgn0015011
Locus tag
Dmel_CG8956
See related
AllianceGenome:FB:FBgn0015011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AHCY; Ahcy89E; CG8956; dAhcyL2; Dmel\CG8956; IRBIT2; pH200; S-AHCY
Summary
Predicted to be involved in S-adenosylmethionine cycle. Predicted to be active in cytosol. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval crystal cell; embryonic/larval garland cell; and fat body. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1) and AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See AhcyL2 in Genome Data Viewer
Location:
89E5-89E5; 3-59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16978439..16982158, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12804161..12807880, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase M9.7 subunit d Neighboring gene alpha actinin 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45592 Neighboring gene Misexpression suppressor of KSR 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The S-adenosyl-L-homocysteine hydrolase of Drosophila melanogaster: identification, deduced amino acid sequence and cytological localization of the structural gene. Caggese C, et al. Mol Gen Genet, 1997 Jan 27. PMID 9037110
  2. Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein. DeLorenzi M, et al. EMBO J, 1988 Oct. PMID 2903049, Free PMC Article
  3. IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis. Arnaoutov A, et al. iScience, 2020 Mar 27. PMID 32179478, Free PMC Article
  4. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
  5. Mathematical model to predict regions of chromatin attachment to the nuclear matrix. Singh GB, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060438, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables adenosylhomocysteinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosylhomocysteinase like 2
Names
AdoHcyase-like
AhcyL2-PC
AhcyL2-PD
CG8956-PC
CG8956-PD
S-adenosyl homocysteine hydrolase-like
adenosylhomocysteinase 89E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16978439..16982158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206499.2 → NP_996221.1  adenosylhomocysteinase like 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSG0
    Conserved Domains (2) summary
    PRK05476
    Location:63 → 486
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:67 → 491
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

  2. NM_206500.2 → NP_996222.1  adenosylhomocysteinase like 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996222.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P50245, Q27587, Q8MYX7, Q9VEQ4
    Conserved Domains (2) summary
    PRK05476
    Location:63 → 486
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:67 → 491
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50245.2 P50245
Q7KSG0 Q7KSG0

Gene LinkOut

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