U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MEA1 male-enhanced antigen 1 [ Homo sapiens (human) ]

Gene ID: 4201, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
MEA1provided by HGNC
Official Full Name
male-enhanced antigen 1provided by HGNC
Primary source
HGNC:HGNC:6986
See related
Ensembl:ENSG00000124733 MIM:143170; AllianceGenome:HGNC:6986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYS; MEA
Summary
Predicted to be involved in male gonad development. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 41.1), brain (RPKM 13.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MEA1 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43011143..43016886, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42840241..42845985, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42978881..42984624, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CNPY3-GNMT readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42935679-42935875 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42938260-42939130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42939131-42939999 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42946179-42947120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24582 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42947525-42947721 Neighboring gene uncharacterized LOC124900215 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42948960-42949178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17212 Neighboring gene Sharpr-MPRA regulatory region 14905 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42979352-42979852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42988913-42989644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42989645-42990376 Neighboring gene kelch domain containing 3 Neighboring gene ribosomal RNA processing 36 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Lau YF, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2813404, Free PMC Article
  2. Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals. Ohinata Y, et al. DNA Res, 2003 Apr 30. PMID 12755172
  3. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
  4. MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51. Ito N, et al. J Biochem, 2022 May 11. PMID 34964862
  5. Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms. Li J, et al. Mol Syst Biol, 2013 Nov 5. PMID 24189400, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
male-enhanced antigen 1
Names
Male-enhanced antigen (H-Y structural gene)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318942.1 → NP_001305871.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM450289, BM969076, HY039733
    Consensus CDS
    CCDS87405.1
    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000493896.1, ENST00000643776.1
    Conserved Domains (1) summary
    pfam06910
    Location:53 → 168
    MEA1; Male enhanced antigen 1 (MEA1)

  2. NM_001318943.1 → NP_001305872.1  male-enhanced antigen 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AL136304, BM552852, BM969076, DB451970
    Consensus CDS
    CCDS87405.1
    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000494198.1, ENST00000645410.1
    Conserved Domains (1) summary
    pfam06910
    Location:53 → 168
    MEA1; Male enhanced antigen 1 (MEA1)

  3. NM_001363578.1 → NP_001350507.1  male-enhanced antigen 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL136304
    Consensus CDS
    CCDS87406.1
    UniProtKB/TrEMBL
    A0A2R8Y6W5
    Related
    ENSP00000495612.1, ENST00000642748.1
    Conserved Domains (1) summary
    pfam06910
    Location:69 → 184
    MEA1; Male enhanced antigen 1 (MEA1)

  4. NM_014623.4 → NP_055438.1  male-enhanced antigen 1 isoform 1

    See identical proteins and their annotated locations for NP_055438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL136304, BM969076, BQ232807
    Consensus CDS
    CCDS4879.1
    UniProtKB/Swiss-Prot
    Q16626, Q5TC36, Q9BV01
    Related
    ENSP00000244711.3, ENST00000244711.4
    Conserved Domains (1) summary
    pfam06910
    Location:66 → 181
    MEA1; Male enhanced antigen 1 (MEA1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43011143..43016886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446445.2 → XP_024302213.1  male-enhanced antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000493661.1, ENST00000645375.1
    Conserved Domains (1) summary
    pfam06910
    Location:53 → 168
    MEA1; Male enhanced antigen 1 (MEA1)

  2. XM_047418782.1 → XP_047274738.1  male-enhanced antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7W8
    Related
    ENSP00000496447.1, ENST00000642555.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42840241..42845985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355451.1 → XP_054211426.1  male-enhanced antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y7W8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16626.2 GenPept UniProtKB/Swiss-Prot:Q16626

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous