TJP3 tight junction protein 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TJP3provided by CGNC
Full Name: tight junction protein 3provided by CGNC
Primary source: CGNC:478
See related: Ensembl:ENSGALG00010028109
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	28	NC_052559.1 (1405755..1415606, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	28	NC_052600.1 (978611..988450, complement)

Chromosome 28 - NC_052559.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment of endothelial intestinal barrier	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of blood-brain barrier permeability	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein localization to cell-cell junction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tight junction protein ZO-3

Names: tight junction protein 3 (zona occludens 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1405755..1415606 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015299758.4 → XP_015155244.3 tight junction protein ZO-3 isoform X1

UniProtKB/TrEMBL

A0A8V1AF31
XM_040653624.2 → XP_040509558.2 tight junction protein ZO-3 isoform X2

UniProtKB/TrEMBL

A0A8V1AF31
XM_015299757.4 → XP_015155243.3 tight junction protein ZO-3 isoform X1

UniProtKB/TrEMBL

A0A8V1AF31

Related

ENSGALP00010041848.1, ENSGALT00010068105.1
XM_015299760.4 → XP_015155246.2 tight junction protein ZO-3 isoform X5

UniProtKB/TrEMBL

A0A8V1A7C4, A0A8V1AF31

Related

ENSGALP00010041844.1, ENSGALT00010068101.1

Conserved Domains (3) summary

cd12028
Location:524 → 588

SH3_ZO-3; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 3

smart00072
Location:626 → 801

GuKc; Guanylate kinase homologues

cd00992
Location:430 → 508

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_015299759.4 → XP_015155245.2 tight junction protein ZO-3 isoform X4

UniProtKB/TrEMBL

A0A8V1AF31, A0A8V1AJB4

Related

ENSGALP00010041845.1, ENSGALT00010068102.1

Conserved Domains (3) summary

cd12028
Location:568 → 632

SH3_ZO-3; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 3

smart00072
Location:670 → 845

GuKc; Guanylate kinase homologues

cd00992
Location:474 → 552

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_046904621.1 → XP_046760577.1 tight junction protein ZO-3 isoform X3

UniProtKB/TrEMBL

A0A8V1AF31

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

978611..988450 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040692499.2 → XP_040548433.2 tight junction protein ZO-3 isoform X1

UniProtKB/TrEMBL

A0A8V1AF31
XM_040692498.2 → XP_040548432.2 tight junction protein ZO-3 isoform X2

UniProtKB/TrEMBL

A0A8V1AF31
XM_040692497.2 → XP_040548431.2 tight junction protein ZO-3 isoform X1

UniProtKB/TrEMBL

A0A8V1AF31
XM_040692502.2 → XP_040548436.1 tight junction protein ZO-3 isoform X5

UniProtKB/TrEMBL

A0A8V1AF31

Conserved Domains (3) summary

cd12028
Location:524 → 588

SH3_ZO-3; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 3

smart00072
Location:626 → 801

GuKc; Guanylate kinase homologues

cd00992
Location:430 → 508

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...