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CG14882 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41994, updated on 18-Sep-2024

Summary

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Official Symbol
CG14882provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038429
Locus tag
Dmel_CG14882
See related
AllianceGenome:FB:FBgn0038429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD10961; Dmel\CG14882
Summary
Predicted to enable [methionine synthase] reductase activity. Predicted to be involved in methionine biosynthetic process. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and homocystinuria-megaloblastic anemia cblE type. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG14882 in Genome Data Viewer
Location:
89B16-89B16; 3-58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16443207..16445010)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12268929..12270732)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene endosomal maturation defective Neighboring gene Tetratricopeptide repeat domain 1 Neighboring gene Pak3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
  2. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Thanawala SU, et al. Dev Cell, 2013 Apr 15. PMID 23597484, Free PMC Article
  3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
  5. A genome-wide resource for the analysis of protein localisation in Drosophila. Sarov M, et al. Elife, 2016 Feb 20. PMID 26896675, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables [methionine synthase] reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methionine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14882-PA
CG14882-PB
NP_001262637.1
NP_650544.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16443207..16445010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275708.1 → NP_001262637.1  uncharacterized protein Dmel_CG14882, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262637.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TF6, Q9VEV2
    Conserved Domains (1) summary
    cd06203
    Location:66 → 453
    methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

  2. NM_142287.2 → NP_650544.1  uncharacterized protein Dmel_CG14882, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TF6, Q9VEV2
    Related
    FBpp0082740
    Conserved Domains (1) summary
    cd06203
    Location:66 → 453
    methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TF6 Q95TF6
Q9VEV2 Q9VEV2

Gene LinkOut

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