DRAXIN dorsal inhibitory axon guidance protein [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: DRAXINprovided by CGNC
Official Full Name: dorsal inhibitory axon guidance proteinprovided by CGNC
Primary source: CGNC:3428
See related: Ensembl:ENSGALG00010021184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: UNQ3119; neucrin; AGPA3119; C1orf187; C21H1ORF187
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (5638646..5654973, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (5672745..5689082, complement)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.
Title: Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT.
Loss of Draxin results in blocking laminin remodeling at the regression stage.
Title: Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT.
draxin might be involved in the fascicular projection of cranial nerves in the hindbrain.
Title: Potential Involvement of Draxin in the Axonal Projection of Cranial Nerves, Especially Cranial Nerve X, in the Chick Hindbrain.
Draxin, an axon guidance protein, can also affect trunk neural crest migration in the chick embryo.
Title: Draxin, an axon guidance protein, affects chick trunk neural crest migration.
Results suggest that draxin may be an important member of the collection of repulsive guidance molecules that regulate the formation of the ventrally directed tectum axon tracts.
Title: Analysis of a repulsive axon guidance molecule, draxin, on ventrally directed axon projection in chick early embryonic midbrain.
findings show draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures
Title: Draxin, a repulsive guidance protein for spinal cord and forebrain commissures.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: draxin

Names: neural tissue-specific cysteine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142848.3 → NP_001136320.2 draxin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000329

UniProtKB/Swiss-Prot

B6ZI38

UniProtKB/TrEMBL

A0A8V0ZP99

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5638646..5654973 complement

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GenBank, FASTA, Sequence Viewer (Graphics)