U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG31183 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41927, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CG31183provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051183
Locus tag
Dmel_CG31183
See related
AllianceGenome:FB:FBgn0051183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11846; CG4224; Dmel\CG31183; DrGC-2; FBgn0038379; GYC; Gyc89A
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process; cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; essential hypertension; and myocardial infarction. Orthologous to several human genes including NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG31183 in Genome Data Viewer
Location:
89A6-89A7; 3-58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15857871..15875939, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11683593..11701661, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene crossveinless d Neighboring gene uncharacterized protein Neighboring gene Heavy metal tolerance factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene globin 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification, characterization, and developmental regulation of a receptor guanylyl cyclase expressed during early stages of Drosophila development. McNeil L, et al. J Biol Chem, 1995 Mar 31. PMID 7706258
  2. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
  3. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob JC, et al. J Neurosci, 2004 Jul 28. PMID 15282266, Free PMC Article
  4. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
  5. E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila. Duvall LB, et al. J Biol Rhythms, 2013 Aug. PMID 23929551, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c15872078-15871761 mobile_element_type = transposon:INE-1{}5713

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG31183-PA
CG31183-PB
guanylyl cyclase at 89A
NP_001287342.1
NP_650505.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15857871..15875939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300413.1 → NP_001287342.1  uncharacterized protein Dmel_CG31183, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287342.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF17
    Conserved Domains (7) summary
    cd06373
    Location:88 → 498
    PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
    smart00044
    Location:917 → 1108
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:589 → 883
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:944 → 1130
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:108 → 473
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:893 → 938
    HNOBA; Heme NO binding associated
    pfam07714
    Location:613 → 877
    Pkinase_Tyr; Protein tyrosine kinase

  2. NM_142248.3 → NP_650505.2  uncharacterized protein Dmel_CG31183, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650505.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF17
    Related
    FBpp0082641
    Conserved Domains (7) summary
    cd06373
    Location:88 → 498
    PBP1_NPR_like; Ligand binding domain of natriuretic peptide receptor (NPR) family
    smart00044
    Location:917 → 1108
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:589 → 883
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:944 → 1130
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:108 → 473
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:893 → 938
    HNOBA; Heme NO binding associated
    pfam07714
    Location:613 → 877
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961R7 Q961R7
Q9VF17 Q9VF17

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools