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AOX3 Aldehyde oxidase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41896, updated on 18-Sep-2024

Summary

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Official Symbol
AOX3provided by FlyBase
Official Full Name
Aldehyde oxidase 3provided by FlyBase
Primary source
FLYBASE:FBgn0038349
Locus tag
Dmel_CG6045
See related
AllianceGenome:FB:FBgn0038349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6045; DmAO3; Dmel\CG6045
Summary
Enables aldehyde oxidase activity. Involved in acetaldehyde metabolic process. Is expressed in adult head; embryonic antennal sense organ; embryonic precursor of adult hindgut; embryonic/larval midgut; and organism. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See AOX3 in Genome Data Viewer
Location:
88F7-88F7; 3-57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15542748..15548188, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11368470..11373458, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Aldehyde oxidase 1 Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
  2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
  3. In Depth Exploration of the Alternative Proteome of Drosophila melanogaster. Fabre B, et al. Front Cell Dev Biol, 2022. PMID 35721519, Free PMC Article
  4. Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Monzo K, et al. Dev Biol, 2010 Apr 15. PMID 20122915, Free PMC Article
  5. The hemolymph proteome of fed and starved Drosophila larvae. Handke B, et al. PLoS One, 2013. PMID 23840627, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetaldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
aldehyde oxidase 3
Names
AOX3-PA
AOX3-PB
CG6045-PA
CG6045-PB
NP_001303439.1
NP_650477.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15542748..15548188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316510.1 → NP_001303439.1  aldehyde oxidase 3, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS1, Q9VF51
    Conserved Domains (6) summary
    smart01008
    Location:540 → 646
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    PLN02906
    Location:24 → 1238
    PLN02906; xanthine dehydrogenase
    pfam01799
    Location:80 → 153
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:688 → 1172
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:386 → 487
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
    cl19922
    Location:201 → 360
    FAD_binding_4; FAD binding domain

  2. NM_142220.2 → NP_650477.1  aldehyde oxidase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650477.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NS1, Q9VF51
    Related
    FBpp0082605
    Conserved Domains (6) summary
    smart01008
    Location:540 → 646
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    PLN02906
    Location:24 → 1238
    PLN02906; xanthine dehydrogenase
    pfam01799
    Location:80 → 153
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:688 → 1172
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:386 → 487
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
    cl19922
    Location:201 → 360
    FAD_binding_4; FAD binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXA6 Q8SXA6
Q9VF51 Q9VF51

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