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Act88F Actin 88F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41885, updated on 18-Sep-2024

Summary

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Official Symbol
Act88Fprovided by FlyBase
Official Full Name
Actin 88Fprovided by FlyBase
Primary source
FLYBASE:FBgn0000047
Locus tag
Dmel_CG5178
See related
AllianceGenome:FB:FBgn0000047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
act 88F; Act(88F); Act88-F; act88F; Act88f; ACT88F; actin; Actin; Actin88F; ArpD; CG5178; Dmel\CG5178; E; Ifm(3)7; P83967; rsd
Summary
Involved in muscle thin filament assembly and skeletal myofibril assembly. Located in Z disc. Is expressed in adult head; spermatozoon; and thorax. Used to study congenital structural myopathy; myopathy; and nemaline myopathy. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Act88F in Genome Data Viewer
Location:
88F5-88F5; 3-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15439969..15442177)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11265691..11267899)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45911 Neighboring gene mir-2c stem loop Neighboring gene uncharacterized protein Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif A Neighboring gene snoRNA:Orphan H/ACA box 9 Neighboring gene B9d1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis of IFM-specific actin and myosin nulls in Drosophila melanogaster unravels lesion-specific expression blueprints across muscle mutations. Madan A, et al. Gene, 2017 Oct 5. PMID 28739398
  2. Transplanted wing and leg imaginal discs in Drosophila melanogaster demonstrate interactions between epidermis and myoblasts in muscle formation. Raghavan KV, et al. Dev Genes Evol, 1996 Jun. PMID 24173396
  3. Dominant negative mutant actins identified in flightless Drosophila can be classified into three classes. Noguchi TQ, et al. J Biol Chem, 2010 Feb 12. PMID 19933578, Free PMC Article
  4. Role of calcium in the regulation of mechanical power in insect flight. Gordon S, et al. Proc Natl Acad Sci U S A, 2006 Mar 14. PMID 16537527, Free PMC Article
  5. Molecular characterization of mutant actin genes which induce heat-shock proteins in Drosophila flight muscles. Okamoto H, et al. EMBO J, 1986 Mar. PMID 16453675, Free PMC Article

See all (273) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate a role for CF2 as a direct negative regulator of the thin filament protein gene Actin 88F.
    Title: CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.
  2. Results report on the structure and in situ location of arthrin (monoubiquitinated actin).
    Title: Structural studies of arthrin: monoubiquitinated actin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle thin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle thin filament HDA PubMed 

General protein information

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Preferred Names
actin 88F
Names
88F actin
Act88F-PA
CG5178-PA
F-actin
actin
actin88F
arthrin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15439969..15442177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079643.2 → NP_524367.1  actin 88F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524367.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83967
    UniProtKB/TrEMBL
    B6IDW7, C6TP14
    Related
    FBpp0082597
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83967.1 P83967

Gene LinkOut

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