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Ccm3 Cerebral cavernous malformation 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41876, updated on 2-Nov-2024

Summary

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Official Symbol
Ccm3provided by FlyBase
Official Full Name
Cerebral cavernous malformation 3provided by FlyBase
Primary source
FLYBASE:FBgn0038331
Locus tag
Dmel_CG5073
See related
AllianceGenome:FB:FBgn0038331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CCM3; CG5073; Dmel\CG5073
Summary
Predicted to enable protein kinase binding activity. Involved in trachea morphogenesis. Part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including adult fat body; adult head; adult heart; embryonic proventriculus; and embryonic proventriculus inner layer. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ccm3 in Genome Data Viewer
Location:
88F2-88F3; 3-57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15371957..15374237)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11197679..11199959)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RIM-binding protein Neighboring gene heineken-cup Neighboring gene antisense RNA:CR46058 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Nishimura S, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28500274, Free PMC Article
  2. STRIPAK complexes: structure, biological function, and involvement in human diseases. Hwang J, et al. Int J Biochem Cell Biol, 2014 Feb. PMID 24333164, Free PMC Article
  3. Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2. Song Y, et al. Dev Cell, 2013 Jun 10. PMID 23763949, Free PMC Article
  4. MST kinases in development and disease. Thompson BJ, et al. J Cell Biol, 2015 Sep 14. PMID 26370497, Free PMC Article
  5. A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation. Neisch AL, et al. J Cell Biol, 2017 Feb. PMID 28100687, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.
    Title: NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.
  2. CCM3 and GCKIII prevent tube dilation in Drosophila trachea; tube dilation is suppressed by reduction of NSF2
    Title: Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cerebral cavernous malformation 3
Names
CG5073-PA
Ccm3-PA
cerebral cavernous malformation 3 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15371957..15374237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142202.3 → NP_650459.1  cerebral cavernous malformation 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650459.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF70
    Related
    FBpp0082550
    Conserved Domains (1) summary
    pfam06840
    Location:8 → 156
    DUF1241; Protein of unknown function (DUF1241)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF70 Q9VF70

Gene LinkOut

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