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MCF2L MCF.2 cell line derived transforming sequence like [ Gallus gallus (chicken) ]

Gene ID: 418748, updated on 17-Aug-2024

Summary

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Symbol
MCF2Lprovided by CGNC
Full Name
MCF.2 cell line derived transforming sequence likeprovided by CGNC
Primary source
CGNC:12632
See related
Ensembl:ENSGALG00010014903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MCF2L in Genome Data Viewer
Location:
chromosome: 1
Exon count:
45
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (137620567..137768881, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (137619880..137768229, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene coagulation factor X Neighboring gene coagulation factor VII Neighboring gene ATPase phospholipid transporting 11A Neighboring gene tubulin gamma complex associated protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor DBS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397798.1 → NP_001384727.1  guanine nucleotide exchange factor DBS isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000025
    UniProtKB/TrEMBL
    A0A8V0YQE0
    Related
    ENSGALP00010020870.1, ENSGALT00010035951.1

  2. NM_001397799.1 → NP_001384728.1  guanine nucleotide exchange factor DBS isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000025
    UniProtKB/TrEMBL
    A0A8V0YIX5, A0A8V0YQC5
    Related
    ENSGALP00010020868.1, ENSGALT00010035949.1

  3. NM_001397800.1 → NP_001384729.1  guanine nucleotide exchange factor DBS isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000025
    UniProtKB/TrEMBL
    A0A8V0YQC0

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    137620567..137768881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277843.4 → XP_015133329.2  guanine nucleotide exchange factor DBS isoform X5

    UniProtKB/TrEMBL
    A0A8V0YQD5, A0A8V0YS34
    Related
    ENSGALP00010020874.1, ENSGALT00010035964.1
    Conserved Domains (5) summary
    cd11857
    Location:1110 → 1164
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:79 → 224
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:635 → 812
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:359 → 557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:819 → 950
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  2. XM_040699285.2 → XP_040555219.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    A0A8V0YQE0
    Conserved Domains (5) summary
    cd11857
    Location:1073 → 1127
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:87 → 232
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:643 → 820
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:367 → 565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:827 → 958
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_040699251.2 → XP_040555185.1  guanine nucleotide exchange factor DBS isoform X3

    UniProtKB/TrEMBL
    A0A8V0YQD5
    Conserved Domains (5) summary
    cd11857
    Location:1118 → 1172
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:87 → 232
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:643 → 820
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:367 → 565
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:827 → 958
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_040699276.2 → XP_040555210.1  guanine nucleotide exchange factor DBS isoform X8

    UniProtKB/TrEMBL
    A0A8V0YQC1
    Related
    ENSGALP00010020863.1, ENSGALT00010035944.1
    Conserved Domains (5) summary
    cd11857
    Location:1077 → 1131
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602 → 779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786 → 917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  5. XM_046941155.1 → XP_046797111.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    A0A8V0YQC0

  6. XM_040699270.2 → XP_040555204.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    A0A8V0YIX5
    Related
    ENSGALP00010020861.1, ENSGALT00010035942.1
    Conserved Domains (5) summary
    cd11857
    Location:1091 → 1145
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:60 → 205
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:616 → 793
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:340 → 538
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:800 → 931
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  7. XM_040699263.1 → XP_040555197.1  guanine nucleotide exchange factor DBS isoform X6

    UniProtKB/TrEMBL
    A0A8V0YQC1
    Conserved Domains (5) summary
    cd11857
    Location:1036 → 1090
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:330 → 528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  8. XM_040699242.2 → XP_040555176.1  guanine nucleotide exchange factor DBS isoform X2

    UniProtKB/TrEMBL
    A0A8V0YQC1
    Related
    ENSGALP00010020857.1, ENSGALT00010035938.1
    Conserved Domains (5) summary
    cd11857
    Location:1061 → 1115
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:330 → 528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  9. XM_040699256.2 → XP_040555190.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    A0A8V0YQC1
    Conserved Domains (5) summary
    cd11857
    Location:1056 → 1110
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:330 → 528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  10. XM_040699234.2 → XP_040555168.1  guanine nucleotide exchange factor DBS isoform X1

    UniProtKB/TrEMBL
    A0A8V0YQC1
    Conserved Domains (5) summary
    cd11857
    Location:1081 → 1135
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606 → 783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:330 → 528
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790 → 921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  11. XM_040699294.2 → XP_040555228.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    A0A8V0YQC0
    Conserved Domains (5) summary
    cd11857
    Location:1048 → 1102
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573 → 750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:297 → 495
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757 → 888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  12. XM_040699281.2 → XP_040555215.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    A0A8V0YQC0
    Related
    ENSGALP00010020855.1, ENSGALT00010035936.1
    Conserved Domains (5) summary
    cd11857
    Location:1075 → 1129
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600 → 777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:324 → 522
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784 → 915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  13. XM_040699288.2 → XP_040555222.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/TrEMBL
    A0A8V0YQC0
    Conserved Domains (5) summary
    cd11857
    Location:1058 → 1112
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:27 → 172
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:583 → 760
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:307 → 505
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:767 → 898
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  14. XM_046941160.1 → XP_046797116.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    A0A8V0YQC0

  15. XM_040699299.2 → XP_040555233.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    A0A8V0YQC0
    Conserved Domains (4) summary
    cd11857
    Location:918 → 972
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    cd00160
    Location:443 → 620
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:167 → 365
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:627 → 758
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    137619880..137768229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908095.1 → XP_046764051.1  guanine nucleotide exchange factor DBS isoform X5

    UniProtKB/TrEMBL
    A0A8V0YQD5

  2. XM_046908100.1 → XP_046764056.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    A0A8V0YQE0

  3. XM_046908093.1 → XP_046764049.1  guanine nucleotide exchange factor DBS isoform X3

    UniProtKB/TrEMBL
    A0A8V0YQD5

  4. XM_046908098.1 → XP_046764054.1  guanine nucleotide exchange factor DBS isoform X8

    UniProtKB/TrEMBL
    A0A8V0YQC1

  5. XM_046908103.1 → XP_046764059.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    A0A8V0YQC0

  6. XM_046908097.1 → XP_046764053.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    A0A8V0YIX5

  7. XM_046908096.1 → XP_046764052.1  guanine nucleotide exchange factor DBS isoform X6

    UniProtKB/TrEMBL
    A0A8V0YQC1

  8. XM_046908092.1 → XP_046764048.1  guanine nucleotide exchange factor DBS isoform X2

    UniProtKB/TrEMBL
    A0A8V0YQC1

  9. XM_046908094.1 → XP_046764050.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    A0A8V0YQC1

  10. XM_046908091.1 → XP_046764047.1  guanine nucleotide exchange factor DBS isoform X1

    UniProtKB/TrEMBL
    A0A8V0YQC1

  11. XM_046908102.1 → XP_046764058.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    A0A8V0YQC0

  12. XM_046908099.1 → XP_046764055.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    A0A8V0YQC0

  13. XM_046908101.1 → XP_046764057.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/TrEMBL
    A0A8V0YQC0

  14. XM_046908105.1 → XP_046764061.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    A0A8V0YQC0

  15. XM_046908104.1 → XP_046764060.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    A0A8V0YQC0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001252063.1: Suppressed sequence

    Description
    NM_001252063.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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