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HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 [ Gallus gallus (chicken) ]

Gene ID: 418682, updated on 10-Oct-2024

Summary

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Symbol
HERC2provided by CGNC
Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by CGNC
Primary source
CGNC:12553
See related
Ensembl:ENSGALG00010002886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See HERC2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
94
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (130613024..130718286)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (130568938..130674056)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051964 Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 1 Neighboring gene uncharacterized LOC100858753 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene uncharacterized LOC121107738

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells. Oestergaard VH, et al. DNA Repair (Amst), 2012 Nov 1. PMID 23010445
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HERC2 is not required for survival or for ubiquitin foci formation after DNA damage in DT40.
    Title: RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HERC2
Names
hect domain and RLD 2
NP_001239305.2
XP_015133198.2
XP_015133199.2
XP_040555018.1
XP_040555024.1
XP_046764006.1
XP_046764007.1
XP_046764008.1
XP_046764009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252376.3 → NP_001239305.2  E3 ubiquitin-protein ligase HERC2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000025
    Conserved Domains (5) summary
    cd08664
    Location:2769 → 2914
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2956 → 3326
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4426 → 4797
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2710 → 2754
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2462 → 2509
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    130613024..130718286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277713.4 → XP_015133199.2  E3 ubiquitin-protein ligase HERC2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XBP7
    Related
    ENSGALP00010004096.1, ENSGALT00010006692.1
    Conserved Domains (5) summary
    cd08664
    Location:2769 → 2914
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2956 → 3326
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4390 → 4761
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2710 → 2754
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2462 → 2509
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

  2. XM_015277712.4 → XP_015133198.2  E3 ubiquitin-protein ligase HERC2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XBP7, A0A8V0XEM6
    Related
    ENSGALP00010004094.1, ENSGALT00010006688.1
    Conserved Domains (5) summary
    cd08664
    Location:2764 → 2909
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2951 → 3321
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4421 → 4792
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2705 → 2749
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2457 → 2504
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

  3. XM_040699084.2 → XP_040555018.1  E3 ubiquitin-protein ligase HERC2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XBP7
    Conserved Domains (5) summary
    cd08664
    Location:2769 → 2914
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2956 → 3326
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4426 → 4797
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2710 → 2754
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2462 → 2509
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

  4. XM_040699090.2 → XP_040555024.1  E3 ubiquitin-protein ligase HERC2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XBP7, A0A8V0XEM6
    Conserved Domains (5) summary
    cd08664
    Location:2764 → 2909
    APC10-HERC2; APC10-like DOC1 domain present in HERC2 (HECT domain and RLD2)
    COG5184
    Location:2951 → 3321
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4421 → 4792
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd02344
    Location:2705 → 2749
    ZZ_HERC2; Zinc finger, ZZ type. Zinc finger present in HERC2 and related proteins. HERC2 is a potential E3 ubiquitin protein ligase and/or guanine nucleotide exchange factor. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or ...
    cd14402
    Location:2457 → 2504
    UBA_HERC2; UBA domain found in probable E3 ubiquitin-protein ligase HERC2 and similar proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    130568938..130674056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908053.1 → XP_046764009.1  E3 ubiquitin-protein ligase HERC2 isoform X3

  2. XM_046908051.1 → XP_046764007.1  E3 ubiquitin-protein ligase HERC2 isoform X2

  3. XM_046908050.1 → XP_046764006.1  E3 ubiquitin-protein ligase HERC2 isoform X1

  4. XM_046908052.1 → XP_046764008.1  E3 ubiquitin-protein ligase HERC2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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