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Tmtc4 Transmembrane O-mannosyltransferase targeting cadherins 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41867, updated on 2-Nov-2024

Summary

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Official Symbol
Tmtc4provided by FlyBase
Official Full Name
Transmembrane O-mannosyltransferase targeting cadherins 4provided by FlyBase
Primary source
FLYBASE:FBgn0038324
Locus tag
Dmel_CG5038
See related
AllianceGenome:FB:FBgn0038324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5038; Dmel\CG5038; TMTC4
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human TMTC4 (transmembrane O-mannosyltransferase targeting cadherins 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Tmtc4 in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15351225..15353926)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11176947..11179648)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 33 Neighboring gene Autophagy-related 4b Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene Translin associated factor X Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
  2. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
  3. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article
  4. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
  5. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane O-mannosyltransferase targeting cadherins 4
Names
CG5038-PA
Tmtc4-PA
NP_650451.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15351225..15353926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142194.3 → NP_650451.1  transmembrane O-mannosyltransferase targeting cadherins 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VF81
    Related
    FBpp0082545
    Conserved Domains (5) summary
    COG0457
    Location:442 → 701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:480 → 506
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:546 → 577
    TPR_1; Tetratricopeptide repeat
    pfam08409
    Location:258 → 331
    DUF1736; Domain of unknown function (DUF1736)
    pfam13431
    Location:466 → 499
    TPR_17; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF81.1 Q9VF81

Gene LinkOut

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