HBA1 hemoglobin subunit alpha 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: HBA1provided by CGNC
Full Name: hemoglobin subunit alpha 1provided by CGNC
Primary source: CGNC:50310
See related: Ensembl:ENSGALG00010019732
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HBAA; alpha-A-globin
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Genomic context

Location:: chromosome: 14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (12118602..12119420)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (12114239..12115057)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that the Upstream Enhancer Element activity contributes to the positioning of a nucleosome that is necessary for the alpha-globin 3' enhancer activation
Title: A regulatory element affects the activity and chromatin structure of the chicken α-globin 3' enhancer.
Epigenetic mechanisms are necessary for in vivo chicken alpha-globin gene switching through differential gene silencing of the embryonic alpha-globin gene in order to allow proper activation of adult alpha-globin genes.
Title: Chicken alpha-globin switching depends on autonomous silencing of the embryonic pi globin gene by epigenetics mechanisms.
active transcription of the housekeeping gene overlapping the alpha-globin gene domain enables an access of Origin Recognition Complex proteins to the replication origin resulting in early replication of alpha-globin genes even in non-erythroid cells.
Title: Early replication timing of the chicken alpha-globin gene domain correlates with its open chromatin state in cells of different lineages.
Spatial organization of the chicken HBA2 and HBA1 gene domains is different in erythroid and non-erythroid cells.
Title: Study of spatial organization of chicken alpha-globin gene domain by 3C technique.
Data show that the upstream area of the chicken alpha-globin gene domain is transcribed in both directions in the same cells.
Title: The upstream area of the chicken alpha-globin gene domain is transcribed in both directions in the same cells.
in avian erythroblastosis virus-transformed chicken erythroleukaemic cells, where globin gene expression is abortive, the whole domain of alpha-globin genes is transcribed for about 33 kb in the globin direction and this RNA is part of the nuclear matrix
Title: The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables haptoglobin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables organic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IEA Inferred from Electronic Annotation more info	PubMed
part_of haptoglobin-hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit alpha-A

Names: adult alpha A globin; alpha-A globin; hemoglobin alpha, subunit A; hemoglobin alpha, subunit?A; hemoglobin alpha-A chain; hemoglobin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.