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HBAD hemoglobin alpha, subunit D [ Gallus gallus (chicken) ]

Gene ID: 416651, updated on 19-Sep-2023

Summary

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Symbol
HBADprovided by CGNC
Full Name
hemoglobin alpha, subunit Dprovided by CGNC
Primary source
CGNC:50309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HBM; HBA2
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Genomic context

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See HBAD in Genome Data Viewer
Location:
chromosome: 14
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (12115577..12116504)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (12111215..12112142)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene nitrogen permease regulator-like 3 (S. cerevisiae) Neighboring gene hemoglobin subunit zeta Neighboring gene hemoglobin subunit alpha 1 Neighboring gene transmembrane protein 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid sequence of the alpha chain of chicken AI hemoglobin. Takei H, et al. J Biochem, 1975 Jun. PMID 1225908
  2. Indefinite noncooperative self-association of chicken deoxy hemoglobin D. Rana MS, et al. Proteins, 2011 May. PMID 21337627
  3. Study of spatial organization of chicken alpha-globin gene domain by 3C technique. Gavrilov AA, et al. Biochemistry (Mosc), 2008 Nov. PMID 19120022
  4. The structural and functional analysis of the hemoglobin D component from chicken. Knapp JE, et al. J Biol Chem, 1999 Mar 5. PMID 10037733
  5. Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. Chapman BS, et al. J Biol Chem, 1982 Jan 25. PMID 7054172

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this model, the deoxy hemoglobin D associates noncooperatively to give a linear oligomeric chain with an equilibrium association constant of 1.42 x 10(4) M(-1) at 20 degrees C for each step.
    Title: Indefinite noncooperative self-association of chicken deoxy hemoglobin D.
  2. Spatial organization of the chicken HBA2 and HBA1 gene domains is different in erythroid and non-erythroid cells.
    Title: Study of spatial organization of chicken alpha-globin gene domain by 3C technique.
  3. in avian erythroblastosis virus-transformed chicken erythroleukaemic cells, where globin gene expression is abortive, the whole domain of alpha-globin genes is transcribed for about 33 kb in the globin direction and this RNA is part of the nuclear matrix
    Title: The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables haptoglobin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables organic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oxygen transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of haptoglobin-hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hemoglobin subunit alpha-D
Names
adult alpha D globin
alpha-D-globin
hemoglobin alpha-D chain
hemoglobin subunit mu
hemoglobin, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004375.3 → NP_001004375.1  hemoglobin subunit alpha-D

    See identical proteins and their annotated locations for NP_001004375.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000257
    UniProtKB/Swiss-Prot
    P02001, Q549K7, Q78AJ9
    Conserved Domains (1) summary
    cd08927
    Location:2 → 141
    Hb-alpha-like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12115577..12116504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12111215..12112142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02001.1 GenPept UniProtKB/Swiss-Prot:P02001

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials