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Lip3 Lipase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41643, updated on 2-Nov-2024

Summary

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Official Symbol
Lip3provided by FlyBase
Official Full Name
Lipase 3provided by FlyBase
Primary source
FLYBASE:FBgn0023495
Locus tag
Dmel_CG8823
See related
AllianceGenome:FB:FBgn0023495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8823; dLip3; Dmel\CG8823; Dmlip3; lip3; LIP3; LIP3Dm
Summary
Enables phospholipase activity and triacylglycerol lipase activity. Involved in lipid catabolic process. Is expressed in embryonic/larval fat body; follicle cell; oocyte; organism; and ovary. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Lip3 in Genome Data Viewer
Location:
87E8-87E8; 3-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13370240..13371904, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9195962..9197626, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene methuselah-like 12 Neighboring gene Elongator complex protein 6 Neighboring gene Dicarboxylate carrier 1 Neighboring gene Chemosensory protein A 87a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improving on nature's shortcomings: evolving a lipase for increased lipolytic activity, expression and thermostability. Alfaro-Chávez AL, et al. Protein Eng Des Sel, 2019 Sep 10. PMID 31403166
  2. Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. Voelzmann A, et al. FEBS Lett, 2016 Apr. PMID 26950647
  3. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. Sellin J, et al. J Insect Physiol, 2020 Oct. PMID 32730782
  4. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
  5. Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. Ambrosio L, et al. PLoS One, 2014. PMID 25133712, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
NOT enables monoacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables triacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipase 3
Names
CG8823-PA
Lip3-PA
Lipase-3
dLipase-3
lipase3
NP_477331.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13370240..13371904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057983.4 → NP_477331.1  lipase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477331.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46108, Q4V3U9
    UniProtKB/TrEMBL
    Q4V3V4
    Related
    FBpp0082239
    Conserved Domains (3) summary
    PLN02872
    Location:26 → 392
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:30 → 89
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:315 → 355
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46108.1 O46108

Gene LinkOut

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