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apn apnoia [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41631, updated on 2-Nov-2024

Summary

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Official Symbol
apnprovided by FlyBase
Official Full Name
apnoiaprovided by FlyBase
Primary source
FLYBASE:FBgn0038132
Locus tag
Dmel_CG15887
See related
AllianceGenome:FB:FBgn0038132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Apn; BcDNA:RE53127; CG15887; Dmel\CG15887
Summary
Involved in positive regulation of protein localization to membrane and respiratory system development. Located in apical plasma membrane. Is expressed in adult head; embryonic/larval tracheal section; larval tracheal system; and tracheal fusion cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See apn in Genome Data Viewer
Location:
87E4-87E4; 3-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13287655..13288813, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9113377..9114535, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Osiris 22 Neighboring gene wnt inhibitor of Dorsal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The novel gene apnoia regulates Drosophila tracheal tube size. Scholl A, et al. Dev Dyn, 2019 Jun. PMID 30892787
  2. The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation. Skouloudaki K, et al. PLoS Genet, 2019 Jan. PMID 30645584, Free PMC Article
  3. Form and function of the apical extracellular matrix: new insights from Caenorhabditis elegans, Drosophila melanogaster, and the vertebrate inner ear. Li Zheng S, et al. Fac Rev, 2020. PMID 33659959, Free PMC Article
  4. Cells into tubes: Molecular and physical principles underlying lumen formation in tubular organs. Camelo C, et al. Curr Top Dev Biol, 2021. PMID 33820625
  5. Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster. Bogaerts-Márquez M, et al. Mol Ecol, 2021 Feb. PMID 33350518, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in dorsal trunk growth, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trachea development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in trachea development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apnoia
Names
CG15887-PA
apn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13287655..13288813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142013.3 → NP_650270.1  apnoia [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VFX3
    Related
    FBpp0082244
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFX3.1 Q9VFX3

Gene LinkOut

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