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TBC1D5 TBC1 domain family member 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41628, updated on 2-Nov-2024

Summary

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Official Symbol
TBC1D5provided by FlyBase
Official Full Name
TBC1 domain family member 5provided by FlyBase
Primary source
FLYBASE:FBgn0038129
Locus tag
Dmel_CG8449
See related
AllianceGenome:FB:FBgn0038129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8449; Dmel\CG8449
Summary
Enables small GTPase binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Located in Golgi apparatus. Is expressed in adult fat body and organism. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See TBC1D5 in Genome Data Viewer
Location:
87E3-87E3; 3-53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13269137..13272011, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9094859..9097733, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of variegation 3-7 Neighboring gene ravus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7. Delattre M, et al. Int J Dev Biol, 2002 Jan. PMID 11902679
  2. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. Ye H, et al. Elife, 2020 Apr 14. PMID 32286230, Free PMC Article
  3. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Jemc J, et al. Dev Biol, 2007 Oct 15. PMID 17714699, Free PMC Article
  4. GTPase-activating protein TBC1D5 coordinates with retromer to constrain synaptic growth by inhibiting BMP signaling. Zhou X, et al. J Genet Genomics, 2023 Mar. PMID 36473687
  5. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TBC1 domain family member 5
Names
CG8449-PA
TBC1D5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13269137..13272011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169499.2 → NP_731780.1  TBC1 domain family member 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFX6
    Related
    FBpp0082246
    Conserved Domains (1) summary
    smart00164
    Location:150 → 369
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RV7 Q95RV7
Q9VFX6 Q9VFX6

Gene LinkOut

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