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SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) [ Gallus gallus (chicken) ]

Gene ID: 416236, updated on 17-Aug-2024

Summary

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Official Symbol
SPINK7provided by CGNC
Official Full Name
serine peptidase inhibitor, Kazal type 7 (putative)provided by CGNC
Primary source
CGNC:50205
See related
Ensembl:ENSGALG00010014724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
OM; OVM; SPIK7
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Genomic context

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Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (10179106..10184657)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (10181359..10186934)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor Kazal-type 5-like Neighboring gene uncharacterized LOC101749216 Neighboring gene serine peptidase inhibitor, Kazal type 5 Neighboring gene ovoinhibitor-like Neighboring gene serine protease inhibitor Kazal-type 6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thermodynamic analyses of the constitutive splicing pathway for ovomucoid pre-mRNA. Ro-Choi TS, et al. Mol Cells, 2009 Jun 30. PMID 19533036
  2. Linkage mapping of chicken ovoinhibitor and ovomucoid genes to chromosome 13. Kinoshita K, et al. Anim Genet, 2004 Aug. PMID 15265086
  3. Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Mine Y, et al. Biochem Biophys Res Commun, 2002 Apr 12. PMID 11944924
  4. Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA. Catterall JF, et al. J Cell Biol, 1980 Nov. PMID 7430252, Free PMC Article
  5. Androgens regulate ovomucoid and ovalbumin gene expression independently of estrogen. Compere SJ, et al. J Biol Chem, 1981 Jun 25. PMID 7240208

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that both ovalbumin and ovomucoid were efficiently mutagenized in cultured primordial germ cells (PGCs) by CRISPR/Cas9 system.
    Title: Targeted mutagenesis in chicken using CRISPR/Cas9 system.
  2. turtle-dove (Streptopelia risoria) ovomucoid is differentiated from chicken ovomucoid as it inhibits both trypsin and chymotrypsin to some extent; chick ovomucoid has no effect on chymotrypsin, but completely inhibits trypsin.
    Title: Turtle-dove ovomucoid, a glycoprotein proteinase inhibitor with P1-blood-group antigen activity.
  3. estrogen & steroid hormones work in synergy to increase ovomucoid mRNA synthesis and accumulation in the oviduct; steroid hormones also act independently of estrogen to restimulate transcription of the ovalbumin and ovomucoid genes
    Title: Androgens regulate ovomucoid and ovalbumin gene expression independently of estrogen.
  4. demonstrate that ovomuccoid mRNA has a 24 aa leader sequence and that ovomuccoid but not pre-ovomuccoid has trypsin inhibition activity
    Title: Precursor of egg white ovomucoid. Amino acid sequence of an NH2-terminal extension.
  5. The preferred order of intron removals can be described by a consideration of free energy changes involved in the spliceosomal assembly pathway.
    Title: Thermodynamic analyses of the constitutive splicing pathway for ovomucoid pre-mRNA.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ovomucoid
Names
allergen Gal d 1
allergen Gal d I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112662.2 → NP_001106132.1  ovomucoid isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    B6V1G0
    Conserved Domains (2) summary
    cd01327
    Location:42 → 86
    KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
    pfam00050
    Location:108 → 151
    Kazal_1; Kazal-type serine protease inhibitor domain

  2. NM_001308494.2 → NP_001295423.1  ovomucoid isoform 1 precursor

    See identical proteins and their annotated locations for NP_001295423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAENSK010000256
    UniProtKB/Swiss-Prot
    P01005
    UniProtKB/TrEMBL
    B6V1G0
    Related
    ENSGALP00010020595.1, ENSGALT00010035385.1
    Conserved Domains (2) summary
    cd01327
    Location:42 → 86
    KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...
    pfam00050
    Location:108 → 151
    Kazal_1; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10179106..10184657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10181359..10186934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01005.1 GenPept UniProtKB/Swiss-Prot:P01005

Gene LinkOut

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Research Materials