sim single-minded [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: simprovided by FlyBase
Official Full Name: single-mindedprovided by FlyBase
Primary source: FLYBASE:FBgn0004666
Locus tag: Dmel_CG7771
See related: AllianceGenome:FB:FBgn0004666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0483/09; 0716/08; 0899/14; 0953/08; 1002/10; 1034/02; 1050/13; 1110/04; 1111/10; 1330/08; 1479/04; bHLHe16; CG7771; Dmel\CG7771; l(3)87Ea; l(3)E320; l(3)RD; l(3)s8; l(3)S8; S8; schm; shm; Sim; SIM
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including adult walking behavior; determination of genital disc primordium; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryonic/larval gut; extended germ band embryo; neurons; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1) and SIM2 (SIM bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 87D11-87D11; 3-53 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13057755..13078124)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8883477..8903846)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation.
Title: The bHLH-PAS transcriptional complex Sim:Tgo plays active roles in late oogenesis to promote follicle maturation and ovulation.
Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim.
Title: Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim.
Single-minded directly regulates midline primordium-expressed genes, but in some cases plays a primary role in directing target gene midline expression, and in others provides midline specificity to cell signaling inputs.
Title: Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression.
the number of Sim-Tgo-binding sites is decisive in determining the timing of gene expression in the developing ventral midline.
Title: Temporal regulation of single-minded target genes in the ventral midline of the Drosophila central nervous system.
Single-minded collaborates with Zelda to regulate an evolutionarily dynamic CNS midline cell enhancer
Title: Drosophila melanogaster Zelda and Single-minded collaborate to regulate an evolutionarily dynamic CNS midline cell enhancer.
Different portions of the embryonic gut require sim functions at different times for normal left-right asymmetry.
Title: Roles of single-minded in the left-right asymmetric development of the Drosophila embryonic gut.
results show that Sna has a positive regulatory function on sim expression in the presumptive mesectoderm; this positive effect of Sna depends on the Su(H)-binding sites within the sim promoter, suggesting that Sna regulates Notch signaling
Title: Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression.
acts on identified reg seq of the roughest gene
Title: Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster.
Novel behavioral and developmental defects associated with gene expression
Title: Novel behavioral and developmental defects associated with Drosophila single-minded.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult walking behavior	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectoderm development	TAS Traceable Author Statement more info	PubMed
involved_in locomotion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: single-minded

Names: CG7771-PA; CG7771-PB; CG7771-PC; CG7771-PD; Single-minded; Singled-minded; schmal; sim-PA; sim-PB; sim-PC; sim-PD; single minded; singleminded

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13057755..13078124

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275599.1 → NP_001262528.1 single-minded, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262528.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96521, P05709, Q7KSL7, Q8MQI7, Q9VFZ3

UniProtKB/TrEMBL

A0A0B4KFY1

Conserved Domains (5) summary

smart00091
Location:78 → 139

PAS; PAS domain

cd00083
Location:2 → 54

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:262 → 360

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:78 → 199

PAS; PAS fold

pfam08447
Location:275 → 361

PAS_3; PAS fold
NM_169495.4 → NP_731771.3 single-minded, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731771.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O96521, P05709, Q7KSL7, Q8MQI7, Q9VFZ3

Related

FBpp0082179

Conserved Domains (5) summary

smart00091
Location:78 → 139

PAS; PAS domain

cd00083
Location:2 → 54

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:254 → 352

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:78 → 191

PAS; PAS fold

pfam08447
Location:267 → 353

PAS_3; PAS fold
NM_001275598.2 → NP_001262527.1 single-minded, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262527.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96521, P05709, Q7KSL7, Q8MQI7, Q9VFZ3

UniProtKB/TrEMBL

A0A0B4KH05

Conserved Domains (5) summary

smart00091
Location:89 → 150

PAS; PAS domain

cd00083
Location:13 → 65

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:265 → 363

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:89 → 202

PAS; PAS fold

pfam08447
Location:278 → 364

PAS_3; PAS fold
NM_079616.4 → NP_524340.2 single-minded, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524340.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O96521, P05709, Q7KSL7, Q8MQI7, Q9VFZ3

Related

FBpp0082178

Conserved Domains (5) summary

smart00091
Location:102 → 163

PAS; PAS domain

cd00083
Location:26 → 78

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:278 → 376

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:102 → 215

PAS; PAS fold

pfam08447
Location:291 → 377

PAS_3; PAS fold