CENPT centromere protein T [Gallus gallus (chicken)] - Gene

Summary

Symbol: CENPTprovided by CGNC
Full Name: centromere protein Tprovided by CGNC
Primary source: CGNC:1063
See related: Ensembl:ENSGALG00010021841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CENP-T
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	11	NC_052542.1 (893642..910183, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	11	NC_052583.1 (1064562..1081311, complement)

Chromosome 11 - NC_052542.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions.
Title: Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions.
As the cell cycle is mostly formed from G1, S and G2 phases a gradual loss of CENP-T/W levels is more likely to reflect dependencies associated with kinetochore assembly pre-mitosis and upon entry into mitosis.
Title: Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in kinetochore assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in kinetochore	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: centromere protein T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276313.2 → NP_001263242.2 centromere protein T

Status: VALIDATED

Source sequence(s)

JAENSK010000247

UniProtKB/Swiss-Prot

F1NPG5

UniProtKB/TrEMBL

A0A8V0ZMI0

Related

ENSGALP00010032015.1, ENSGALT00010053142.1

Conserved Domains (1) summary

cl23735
Location:534 → 629

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

893642..910183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015279124.4 → XP_015134610.2 centromere protein T isoform X1

UniProtKB/Swiss-Prot

F1NPG5

Conserved Domains (1) summary

cl23735
Location:523 → 618

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...