BLM Bloom syndrome RecQ like helicase [Gallus gallus (chicken)] - Gene

Summary

Symbol: BLMprovided by CGNC
Full Name: Bloom syndrome RecQ like helicaseprovided by CGNC
Primary source: CGNC:6254
See related: Ensembl:ENSGALG00010016393
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ORF1
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 10

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	10	NC_052541.1 (19935048..19951142, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	10	NC_052582.1 (19798921..19814965, complement)

Chromosome 10 - NC_052541.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

first enzymatic characterization of chicken BLM and its N-terminal domain
Title: Purification and enzymatic characterization of Gallus gallus BLM helicase.
BLM is assembled from dimer into hexamer, and also, the stable DHBN dimer can be dissociated upon ATP hydrolysis. Thus, the structural and biochemical characterizations of N-terminal domains will provide new insights into how the N-terminal domain affects the structural and functional organization of the full BLM molecule.
Title: A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.
Results show that Blm promotes HR between diverged sequences through a novel ATPase-independent mechanism.
Title: Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.
Recql5/blm double mutant cells showed higher frequency of SCE than blm cells.
Title: Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha.
Disruption of the BLM gene in ATM-null DT40 cells (a B-lymphocyte cell line)does not exacerbate either phenotype.
Title: Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype.
These data indicate that BLM and Top3alpha execute the dissolution of sister chromatids.
Title: Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
These data suggest that Fbh1 acts in parallel with Bloom helicase to control recombination-mediated double-strand-break repair at replication blocks and to reduce the frequency of crossover.
Title: Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA unwinding involved in DNA replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in G-quadruplex DNA unwinding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: recQ-like DNA helicase BLM

Names: BLM helicase; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; Gd BLM; recQ helicase homolog

NP_001007088.3

EC 5.6.2.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007087.2 → NP_001007088.3 recQ-like DNA helicase BLM

Status: PROVISIONAL

Source sequence(s)

JAENSK010000246

UniProtKB/TrEMBL

A0A8V0YVN0, D3KR64

Related

ENSGALP00010022807.1, ENSGALT00010039519.1

Conserved Domains (3) summary

smart00341
Location:1181 → 1260

HRDC; Helicase and RNase D C-terminal

TIGR00614
Location:625 → 1111

recQ_fam; ATP-dependent DNA helicase, RecQ family

PRK07003
Location:18 → 146

PRK07003; DNA polymerase III subunit gamma/tau

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

19935048..19951142 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

19798921..19814965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)