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Scgbeta Sarcoglycan beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41525, updated on 2-Nov-2024

Summary

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Official Symbol
Scgbetaprovided by FlyBase
Official Full Name
Sarcoglycan betaprovided by FlyBase
Primary source
FLYBASE:FBgn0038042
Locus tag
Dmel_CG5657
See related
AllianceGenome:FB:FBgn0038042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5657; Dmel\CG5657; DmSCG-beta; dscgbeta; scg-beta
Summary
Predicted to be a structural constituent of muscle. Predicted to be involved in muscle organ development. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; labral sensory complex primordium; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Scgbeta in Genome Data Viewer
Location:
87B9-87B9; 3-52 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12421236..12422429, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8246958..8248151, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dipeptidase C Neighboring gene small non-coding RNA 649 Neighboring gene protein partner of snf Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 1 at 87B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic changes in the subcellular localization of Drosophila beta-sarcoglycan during the cell cycle. Hashimoto R, et al. Cell Struct Funct, 2006. PMID 17159290
  2. Conservation of components of the dystrophin complex in Drosophila. Greener MJ, et al. FEBS Lett, 2000 Sep 29. PMID 11018515
  3. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Dekkers LC, et al. Gene Expr Patterns, 2004 Mar. PMID 15161095
  4. The roles of the dystrophin-associated glycoprotein complex at the synapse. Pilgram GS, et al. Mol Neurobiol, 2010 Feb. PMID 19899002, Free PMC Article
  5. Genetic link between beta-sarcoglycan and the Egfr signaling pathway. Hashimoto R, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16875661

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sarcoglycan complex IEA
Inferred from Electronic Annotation
more info
  
part_of sarcoglycan complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sarcoglycan beta
Names
CG5657-PA
Scgbeta-PA
beta-sarcoglycan
beta-sarcolgycan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12421236..12422429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079603.3 → NP_524327.1  sarcoglycan beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GT65, Q9VG77
    Related
    FBpp0082068
    Conserved Domains (1) summary
    pfam04790
    Location:73 → 330
    Sarcoglycan_1; Sarcoglycan complex subunit protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GT65 Q9GT65
Q9VG77 Q9VG77

Gene LinkOut

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