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CG5196 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41522, updated on 18-Sep-2024

Summary

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Official Symbol
CG5196provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038039
Locus tag
Dmel_CG5196
See related
AllianceGenome:FB:FBgn0038039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5196
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in several structures, including dorsal closure embryo; dorsal sensory complex primordium; embryonic head sensory system; embryonic/larval garland cell; and yolk nucleus. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG5196 in Genome Data Viewer
Location:
87B9-87B9; 3-52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12408316..12411768)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8234038..8237490)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 9f2 Neighboring gene uncharacterized protein Neighboring gene Dipeptidase C Neighboring gene small non-coding RNA 649 Neighboring gene protein partner of snf Neighboring gene Sarcoglycan beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling. Li W, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29180412, Free PMC Article
  2. Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. Knapp JM, et al. Genetics, 2015 Apr. PMID 25680812, Free PMC Article
  3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
  4. Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila. Adewoye AB, et al. J Biol Rhythms, 2017 Oct. PMID 28990443
  5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG5196-PA
CG5196-PB
NP_650191.1
NP_996201.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12408316..12411768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141934.2 → NP_650191.1  uncharacterized protein Dmel_CG5196, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VG80
    Related
    FBpp0082056
    Conserved Domains (1) summary
    pfam01529
    Location:89 → 223
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_206479.2 → NP_996201.1  uncharacterized protein Dmel_CG5196, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWX8
    Conserved Domains (1) summary
    pfam01529
    Location:57 → 191
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWX8 Q8SWX8
Q9VG80 Q9VG80

Gene LinkOut

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