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tpm2 tropomyosin 2 (beta) [ Danio rerio (zebrafish) ]

Gene ID: 415209, updated on 2-Nov-2024

Summary

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Official Symbol
tpm2provided by ZNC
Official Full Name
tropomyosin 2 (beta)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-114
See related
Ensembl:ENSDARG00000104682 AllianceGenome:ZFIN:ZDB-GENE-040625-114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb836; tpm4l; fj63f03; zgc:86810; wu:fj63f03
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in striated muscle thin filament. Is expressed in adaxial cell; cardiovascular system; epiphysis; musculature system; and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tpm2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (6318219..6375129)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (6316987..6373920)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-3-like Neighboring gene talin 1 Neighboring gene zgc:114200 Neighboring gene carbonic anhydrase IX

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the prostaglandin E receptor subtypes 2a and 4b and their expression patterns during embryogenesis in zebrafish. Han Y, et al. Int J Dev Biol, 2021. PMID 34549801
  2. Novel deletion of lysine 7 expands the clinical, histopathological and genetic spectrum of TPM2-related myopathies. Davidson AE, et al. Brain, 2013 Feb. PMID 23413262, Free PMC Article
  3. Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Dube DK, et al. Cytoskeleton (Hoboken), 2017 Mar. PMID 27998020, Free PMC Article
  4. The role of Sox6 in zebrafish muscle fiber type specification. Jackson HE, et al. Skelet Muscle, 2015. PMID 25671076, Free PMC Article
  5. The evolution of compositionally and functionally distinct actin filaments. Gunning PW, et al. J Cell Sci, 2015 Jun 1. PMID 25788699

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tropomyosin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002119.1 → NP_001002119.1  tropomyosin beta chain

    See identical proteins and their annotated locations for NP_001002119.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071471
    UniProtKB/TrEMBL
    A8E5G9, Q6IQD7
    Related
    ENSDARP00000132881.1, ENSDART00000170872.2
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    6318219..6375129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155492.4 → XP_005155549.1  tropomyosin beta chain isoform X3

    UniProtKB/TrEMBL
    A0A8M2B1Q6
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  2. XM_005155494.2 → XP_005155551.1  tropomyosin beta chain isoform X1

    UniProtKB/TrEMBL
    A0A0R4IM99, A0A8M2B1Z0
    Related
    ENSDARP00000136122.1, ENSDART00000158994.3
    Conserved Domains (2) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin
    pfam16526
    Location:13 → 73
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  3. XM_005155493.5 → XP_005155550.1  tropomyosin beta chain isoform X2

    UniProtKB/TrEMBL
    A0A8M2B1K3
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  4. XM_017357954.3 → XP_017213443.1  tropomyosin beta chain isoform X7

    UniProtKB/TrEMBL
    A0A0R4IAL5, A0A8M6Z8R9
    Related
    ENSDARP00000131208.1, ENSDART00000163182.2

  5. XM_005155497.4 → XP_005155554.1  tropomyosin beta chain isoform X5

    UniProtKB/TrEMBL
    A0A8M2B255
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin; Tropomyosin

  6. XM_005155496.5 → XP_005155553.1  tropomyosin beta chain isoform X6

    UniProtKB/TrEMBL
    A0A8M2B2D1
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin; Tropomyosin

  7. XM_005155498.5 → XP_005155555.1  tropomyosin beta chain isoform X4

    UniProtKB/TrEMBL
    A0A8M2B1Q8
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin; Tropomyosin
Nucleotide Protein
Heading Accession and Version

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