hunk.L hormonally up-regulated Neu-associated kinase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hunk.L
Official Full Name: hormonally up-regulated Neu-associated kinase L homeolog
Primary source: Xenbase:XB-GENE-968421
Locus tag: XELAEV_18011506mg
See related: EnsemblRapid:ENSXLAG00005025623 AllianceGenome:Xenbase:XB-GENE-968421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mak; hunk; makv; hunk-A; makv-A
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in mesenchyme; musculoskeletal system; nervous system; pharyngeal arch; and primary germ layer. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (14929163..14992730, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (14711697..14758330, complement)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of xmak-v has been detected in all developmental stages studied including maternal expression in unfertilized eggs
Title: Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hormonally up-regulated neu tumor-associated kinase homolog A

Names: MAK-V/Hunk; Serine/threonine-protein kinase MAK-V A; xMAK-V A

NP_001084712.1

EC 2.7.11.1

XP_041436866.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091243.1 → NP_001084712.1 hormonally up-regulated neu tumor-associated kinase homolog A

Status: PROVISIONAL

Source sequence(s)

BC084068

UniProtKB/Swiss-Prot

Q5XHI9, Q6VZ18

UniProtKB/TrEMBL

A0A974DM02

Related

ENSXLAP00005076164.1, ENSXLAT00005077744.1

Conserved Domains (2) summary

smart00220
Location:55 → 313

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:52 → 313

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

14929163..14992730 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041580932.1 → XP_041436866.1 hormonally up-regulated neu tumor-associated kinase homolog A isoform X1

UniProtKB/TrEMBL

A0A8J1M6D1, A0A974DM02

Related

ENSXLAP00005076292.1, ENSXLAT00005077883.1

Conserved Domains (1) summary

cd14070
Location:86 → 347

STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)