wdr77.S WD repeat domain 77 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wdr77.S
Official Full Name: WD repeat domain 77 S homeolog
Primary source: Xenbase:XB-GENE-972901
Locus tag: XELAEV_18014570mg
See related: EnsemblRapid:ENSXLAG00005029353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mep50; wdr77; MEP-50; valois
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Genomic context

Location:: chromosome: 2S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (35905678..35914641, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (33602494..33611538, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that MEP50 WD repeat protein is essential for methylation of histones H4 and H2A by PRMT5 arginine methyltransferase.
Title: Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.
data support a mechanism in which MEP50 binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications
Title: Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.
Structure of MEP50/Wdr77 in the PRMT5-MEP50 complex
Title: Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.
Wdr77 is now called MEP50 and is a required cofactor of the PRMT5 arginine methyltransferase.
Title: Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs.
Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs
Title: Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of methylosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methylosome protein WDR77

Names: WD repeat-containing protein 77; methylosome protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091234.1 → NP_001084703.1 methylosome protein WDR77

See identical proteins and their annotated locations for NP_001084703.1

Status: PROVISIONAL

Source sequence(s)

BC068665

UniProtKB/Swiss-Prot

Q6NUD0

UniProtKB/TrEMBL

A0A974DGJ3

Related

ENSXLAP00005087670.1, ENSXLAT00005089332.1

Conserved Domains (3) summary

COG2319
Location:73 → 312

WD40; WD40 repeat [General function prediction only]

sd00039
Location:73 → 110

7WD40; WD40 repeat [structural motif]

cl02567
Location:70 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

35905678..35914641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)