acat1.L acetyl-CoA acetyltransferase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: acat1.L
Official Full Name: acetyl-CoA acetyltransferase 1 L homeolog
Primary source: Xenbase:XB-GENE-977287
Locus tag: XELAEV_18003300mg
See related: EnsemblRapid:ENSXLAG00005000676 AllianceGenome:Xenbase:XB-GENE-977287
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: acat1; acat1-a
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity and metal ion binding activity. Predicted to act upstream of or within fatty acid beta-oxidation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (170884619..170903366)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694836.1 (1293287..1312049)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetyl-CoA acetyltransferase A, mitochondrial

Names: Acetoacetyl-CoA thiolase A; acetyl-Coenzyme A acetyltransferase 1

NP_001084679.1

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091210.1 → NP_001084679.1 acetyl-CoA acetyltransferase A, mitochondrial precursor

See identical proteins and their annotated locations for NP_001084679.1

Status: PROVISIONAL

Source sequence(s)

BC068755

UniProtKB/Swiss-Prot

Q6NU46

UniProtKB/TrEMBL

A0A974DL67

Related

ENSXLAP00005001966.1, ENSXLAT00005002012.1

Conserved Domains (2) summary

PLN02644
Location:34 → 420

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:36 → 419

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...