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Spt3 Spt3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41461, updated on 18-Sep-2024

Summary

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Official Symbol
Spt3provided by FlyBase
Official Full Name
Spt3provided by FlyBase
Primary source
FLYBASE:FBgn0037981
Locus tag
Dmel_CG3169
See related
AllianceGenome:FB:FBgn0037981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3169; Dmel\CG3169; dSpt3; SPT3; TFIID
Summary
Predicted to enable transcription coactivator activity. Involved in histone H3 acetylation. Located in nucleus. Part of SAGA complex. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Spt3 in Genome Data Viewer
Location:
87A5-87A5; 3-51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12017156..12018550)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7842878..7844272)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene short spindle 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Li X, et al. Genes Dev, 2017 Aug 1. PMID 28887412, Free PMC Article
  2. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. Torres-Zelada EF, et al. J Cell Sci, 2019 Jan 16. PMID 30559249, Free PMC Article
  3. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. Guelman S, et al. Mol Cell Biol, 2006 Feb. PMID 16428443, Free PMC Article
  4. Two Drosophila Ada2 homologues function in different multiprotein complexes. Kusch T, et al. Mol Cell Biol, 2003 May. PMID 12697829, Free PMC Article
  5. Identification of EMS-induced mutations in Drosophila melanogaster by whole-genome sequencing. Blumenstiel JP, et al. Genetics, 2009 May. PMID 19307605, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Spt3
Names
CG3169-PA
Spt3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12017156..12018550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141889.4 → NP_650146.1  Spt3 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R40, Q9VGE2
    Related
    FBpp0082011
    Conserved Domains (1) summary
    cd07978
    Location:99 → 190
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I8U9 Q8I8U9
Q9VGE2 Q9VGE2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
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