usp44.L ubiquitin specific peptidase 44 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: usp44.L
Official Full Name: ubiquitin specific peptidase 44 L homeolog
Primary source: Xenbase:XB-GENE-1014118
Locus tag: XELAEV_18017490mg
See related: EnsemblRapid:ENSXLAG00005003547 AllianceGenome:Xenbase:XB-GENE-1014118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: usp44; usp44-a; usp44-b
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within negative regulation of ubiquitin protein ligase activity and protein deubiquitination. Predicted to be located in nucleus. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 3L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (63732668..63757772, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (49294972..49320164, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 44-A

Names: Deubiquitinating enzyme 44-A; Ubiquitin thiolesterase 44-A; Ubiquitin-specific-processing protease 44-A; ubiquitin thioesterase 44-A

NP_001084641.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091172.1 → NP_001084641.1 ubiquitin carboxyl-terminal hydrolase 44-A

See identical proteins and their annotated locations for NP_001084641.1

Status: PROVISIONAL

Source sequence(s)

BC068889

UniProtKB/Swiss-Prot

Q6NTR6

UniProtKB/TrEMBL

A0A974HT15

Related

ENSXLAP00005010572.1, ENSXLAT00005010738.1

Conserved Domains (3) summary

cl02553
Location:275 → 665

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:273 → 664

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:26 → 87

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

63732668..63757772 complement

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GenBank, FASTA, Sequence Viewer (Graphics)