ireb2.L iron responsive element binding protein 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ireb2.L
Official Full Name: iron responsive element binding protein 2 L homeolog
Primary source: Xenbase:XB-GENE-943202
Locus tag: XELAEV_18017992mg
See related: EnsemblRapid:ENSXLAG00005036205 AllianceGenome:Xenbase:XB-GENE-943202
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ireb2
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to act upstream of or within intracellular iron ion homeostasis. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (96583684..96619458, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (81270731..81306558, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables iron-responsive element binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within citrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iron-responsive element-binding protein 2

Names: IRE-BP 2; iron-responsive element binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091159.1 → NP_001084628.1 iron-responsive element-binding protein 2

See identical proteins and their annotated locations for NP_001084628.1

Status: PROVISIONAL

Source sequence(s)

BC068915

UniProtKB/Swiss-Prot

Q6NTP2

UniProtKB/TrEMBL

A0A974HTI1

Related

ENSXLAP00005108269.1, ENSXLAT00005110428.1

Conserved Domains (3) summary

cd01580
Location:737 → 906

AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...

PTZ00092
Location:1 → 953

PTZ00092; aconitate hydratase-like protein; Provisional

cl00285
Location:81 → 633

Aconitase; Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

96583684..96619458 complement

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GenBank, FASTA, Sequence Viewer (Graphics)