socs3.L suppressor of cytokine signaling 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: socs3.L
Official Full Name: suppressor of cytokine signaling 3 L homeolog
Primary source: Xenbase:XB-GENE-488203
Locus tag: XELAEV_18043661mg
See related: EnsemblRapid:ENSXLAG00005025633 AllianceGenome:Xenbase:XB-GENE-488203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cis3; ssi3; atod4; cish3; socs3; ssi-3; socs-3; xsocs3
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to act upstream of or within several processes, including intracellular signal transduction; phosphatidylinositol phosphate biosynthetic process; and protein ubiquitination. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including ectoderm; mesenchyme; nervous system; pharyngeal arch; and urinary system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (19438134..19441094)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (18793876..18796836, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 3 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091112.1 → NP_001084581.1 suppressor of cytokine signaling 3 L homeolog

See identical proteins and their annotated locations for NP_001084581.1

Status: PROVISIONAL

Source sequence(s)

BC068752

UniProtKB/TrEMBL

A0A974BX39, Q6NU49

Related

ENSXLAP00005076206.1, ENSXLAT00005077786.1

Conserved Domains (2) summary

cd10384
Location:33 → 133

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 199

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...