aurA aurora A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aurAprovided by FlyBase
Official Full Name: aurora Aprovided by FlyBase
Primary source: FLYBASE:FBgn0000147
Locus tag: Dmel_CG3068
See related: AllianceGenome:FB:FBgn0000147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 87A7-9/2; AAK; aur; Aur; AUR; aur-A; Aur-A; AurA; aurka; AURKA; Aurora A; CG3068; ck10; ck[10]; Dmel\CG3068; l(3)87Ac; l(3)ck10
Summary: Enables protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; microtubule cytoskeleton organization; and pole cell formation. Located in centrosome and cytoplasm. Is expressed in organism and primordial germ cell. Used to study brain cancer. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; spermatogenic failure 5; and uterine cancer. Orthologous to several human genes including AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 87A3-87A3; 3-51 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11963124..11964826)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7788846..7790548)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Title: Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
The data indicate that Aur-A depletion can elicit chromosome damage in Drosophila.
Title: A new role for Drosophila Aurora-A in maintaining chromosome integrity.
AURKA directly regulates mitochondrial functions and that AURKA over-expression promotes metabolic reprogramming by increasing mitochondrial interconnectivity.
Title: Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.
WDR62 controls brain growth through lineage-specific interactions with master mitotic signaling kinase, aurora A kinase.
Title: Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.
equatorial stimulation is mediated primarily by the delivery of factors to the cortex by noncentrosomal microtubules, as well as a midzone-derived phosphorylation gradient that is amplified by the concerted activities of mABK and a soluble pool of AAK.
Title: Aurora A Kinase Amplifies a Midzone Phosphorylation Gradient to Promote High-Fidelity Cytokinesis.
Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Title: Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.
Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
Title: Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.
AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Title: Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Title: Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.
Drosophila melanogaster aurora A phosphorylates the dynactin subunit p150(glued) on sites required for its association with the mitotic spindle.
Title: Aurora A contributes to p150(glued) phosphorylation and function during mitosis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora A

Names: A-type aurora kinase; Aurora-A kinase; AuroraA; CG3068-PA; aurA-PA; aurka; aurora; aurora A kinase; aurora kinase; aurora-A; early-A; fruhe2

NP_476749.1

EC 2.7.11.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11963124..11964826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057401.4 → NP_476749.1 aurora A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476749.1

Status: REVIEWED

UniProtKB/TrEMBL

Q27393, Q9VGF9

Related

FBpp0081957

Conserved Domains (2) summary

smart00220
Location:154 → 406

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14007
Location:153 → 407

STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase