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PGA5 pepsinogen 5, group I (pepsinogen A) [ Bos taurus (domestic cattle) ]

Gene ID: 414350, updated on 4-Oct-2024

Summary

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Gene symbol
PGA5
Gene description
pepsinogen 5, group I (pepsinogen A)
See related
Ensembl:ENSBTAG00000014761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
pga
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Genomic context

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See PGA5 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (39760936..39771371)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene pepsin F Neighboring gene uncharacterized LOC132344201 Neighboring gene pregnancy-associated glycoprotein 8 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene damage specific DNA binding protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the authentic bovine gene encoding pepsinogen a and its expression in microbial cells. Muñoz R, et al. Appl Environ Microbiol, 2004 May. PMID 15128507, Free PMC Article
  2. The activation of bovine pepsinogen. Sequence of the peptides released, identification of a pepsin inhibitor. Harboe M, et al. J Biol Chem, 1974 Jul 25. PMID 4603017
  3. Bovine pepsin: the sequence of the first 65 amino acid residues (completing the sequence of the first 110 residues of bovine pepsinogen). Harboe MK, et al. FEBS Lett, 1975 Dec 1. PMID 776669
  4. High-resolution genetic map of bovine chromosome 29 through focused marker development. Reed KM, et al. Cytogenet Genome Res, 2002. PMID 12438801
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pepsin A
Names
aspartic peptidase
pepsinogen A
pepsinognen A
NP_001001600.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001600.2 → NP_001001600.2  pepsin A preproprotein

    Status: VALIDATED

    Source sequence(s)
    AY330769, DY172617
    UniProtKB/Swiss-Prot
    P00792, Q6VRA9
    UniProtKB/TrEMBL
    F1N373
    Related
    ENSBTAP00000019640.5, ENSBTAT00000019640.6
    Conserved Domains (3) summary
    cd05478
    Location:64 → 384
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam00026
    Location:73 → 385
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:17 → 45
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    39760936..39771371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00792.2 GenPept UniProtKB/Swiss-Prot:P00792

Gene LinkOut

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