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Kyat Kynurenine aminotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41433, updated on 2-Nov-2024

Summary

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Official Symbol
Kyatprovided by FlyBase
Official Full Name
Kynurenine aminotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037955
Locus tag
Dmel_CG6950
See related
AllianceGenome:FB:FBgn0037955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6950; Dmel\CG6950; kyat
Summary
Predicted to enable cysteine-S-conjugate beta-lyase activity and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Kyat in Genome Data Viewer
Location:
86F9-86F9; 3-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11820381..11822493, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7646103..7648215, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shadow

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kynurenine Metabolism in the Fat Body Non-autonomously Regulates Imaginal Disc Repair in Drosophila. Kashio S, et al. iScience, 2020 Dec 18. PMID 33376969, Free PMC Article
  2. Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Brinzer RA, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26474926
  3. Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism. Navrotskaya V, et al. Neurotox Res, 2018 Aug. PMID 29619629
  4. Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging. Oxenkrug G, et al. Exp Biol Med (Maywood), 2023 Apr. PMID 37300401, Free PMC Article
  5. Tryptophan regulates Drosophila zinc stores. Garay E, et al. Proc Natl Acad Sci U S A, 2022 Apr 19. PMID 35412912, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine aminotransferase
Names
CG6950-PA
CG6950-PB
CG6950-PC
CG6950-PD
Kyat-PA
Kyat-PB
Kyat-PC
Kyat-PD
NP_650121.1
NP_731643.2
NP_731644.2
NP_788640.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11820381..11822493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169438.2 → NP_731644.2  kynurenine aminotransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731644.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ5, Q8SXC2, Q9VGH3
    Related
    FBpp0081993
    Conserved Domains (2) summary
    cd00609
    Location:64 → 448
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:56 → 449
    PRK08912; hypothetical protein; Provisional

  2. NM_169437.2 → NP_731643.2  kynurenine aminotransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731643.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ5, Q8SXC2, Q9VGH3
    Related
    FBpp0081994, FBtr0082520
    Conserved Domains (2) summary
    cd00609
    Location:64 → 448
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:56 → 449
    PRK08912; hypothetical protein; Provisional

  3. NM_176463.2 → NP_788640.1  kynurenine aminotransferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ5, Q8SXC2, Q9VGH3
    Related
    FBpp0081996
    Conserved Domains (2) summary
    cd00609
    Location:64 → 448
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:56 → 449
    PRK08912; hypothetical protein; Provisional

  4. NM_141864.2 → NP_650121.1  kynurenine aminotransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650121.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ5, Q8SXC2, Q9VGH3
    Related
    FBpp0081995
    Conserved Domains (2) summary
    cd00609
    Location:64 → 448
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:56 → 449
    PRK08912; hypothetical protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGP9 Q8IGP9
Q8SXC2 Q8SXC2

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