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glo glorund [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41431, updated on 2-Nov-2024

Summary

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Official Symbol
gloprovided by FlyBase
Official Full Name
glorundprovided by FlyBase
Primary source
FLYBASE:FBgn0259139
Locus tag
Dmel_CG6946
See related
AllianceGenome:FB:FBgn0259139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
110/46; anon-WO0118547.328; cg6946; CG6946; Dmel\CG6946; Glo; l(3)S011046; l(3)S11046; p67; p67-K
Summary
Predicted to enable mRNA binding activity. Involved in chromosome organization; oocyte axis specification; and regulation of translation. Part of protein-containing complex. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in Sjogren's syndrome and syndromic X-linked intellectual developmental disorder bain type. Orthologous to several human genes including HNRNPF (heterogeneous nuclear ribonucleoprotein F) and HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See glo in Genome Data Viewer
Location:
86F8-86F9; 3-51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11815206..11819420, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7640928..7645061, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene Chloride channel-a Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene Kynurenine aminotransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Moens TG, et al. Acta Neuropathol, 2018 Mar. PMID 29380049, Free PMC Article
  2. The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos. Warden MS, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37427795, Free PMC Article
  3. The role of HnrnpF/H as a driver of oligoteratozoospermia. Netherton JK, et al. iScience, 2024 Jul 19. PMID 39092172, Free PMC Article
  4. Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo. Andrews S, et al. RNA, 2011 May. PMID 21460235, Free PMC Article
  5. Spatial regulation of nanos is required for its function in dendrite morphogenesis. Brechbiel JL, et al. Curr Biol, 2008 May 20. PMID 18472422, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
    Title: The translational repressor Glorund uses interchangeable RNA recognition domains to recognize Drosophila nanos.
  2. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
    Title: The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
  3. these findings suggest a molecular mechanism for the evolution of dual RNA motif recognition in Glo that may be applied to understanding the functional diversity of other RNA-binding proteins.
    Title: The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition.
  4. Glorund is a component of multiple protein complexes and functions both as a translational repressor and splicing regulator for anterior-posterior and dorsal-ventral patterning.
    Title: Glorund interactions in the regulation of gurken and oskar mRNAs.
  5. These data, together with the analysis of a glorund null mutant, reveal a specific role for an hnRNP in repression of nanos translation during oogenesis.
    Title: Glorund, a Drosophila hnRNP F/H homolog, is an ovarian repressor of nanos translation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular mRNA localization involved in pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glorund
Names
CG6946-PA
CG6946-PB
CG6946-PC
CG6946-PD
glo-PA
glo-PB
glo-PC
glo-PD
p67-K

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11815206..11819420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169435.3 → NP_731640.1  glorund, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INJ6
    Related
    FBpp0088857
    Conserved Domains (2) summary
    COG0724
    Location:20 → 179
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:51 → 125
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_169434.3 → NP_731639.1  glorund, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731639.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGH5
    Related
    FBpp0088856
    Conserved Domains (3) summary
    cd12504
    Location:146 → 224
    RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family
    cd12506
    Location:481 → 555
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cl17169
    Location:51 → 125
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001414143.1 → NP_001401043.1  glorund, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGH5

  4. NM_141863.3 → NP_650120.1  glorund, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650120.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGH5
    Related
    FBpp0088858
    Conserved Domains (3) summary
    cd12504
    Location:146 → 224
    RRM2_hnRNPH_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family
    cd12506
    Location:481 → 555
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cl17169
    Location:51 → 125
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IG99 Q8IG99
Q8INJ6 Q8INJ6
Q9VGH5 Q9VGH5

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