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l(3)neo38 lethal (3) neo38 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41423, updated on 2-Nov-2024

Summary

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Official Symbol
l(3)neo38provided by FlyBase
Official Full Name
lethal (3) neo38provided by FlyBase
Primary source
FLYBASE:FBgn0265276
Locus tag
Dmel_CG6930
See related
AllianceGenome:FB:FBgn0265276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:fe2F4; anon2F4; BcDNA:SD16005; CG14725; CG31364; CG6930; Dmel\CG6930; l(3)NEO38; L(3)neo38
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in brain development and neuromuscular junction development. Located in heterochromatin. Is expressed in several structures, including embryonic/larval midgut primordium; head epidermis primordium; mesoderm; sensory nervous system primordium; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See l(3)neo38 in Genome Data Viewer
Location:
86E18-86E18; 3-51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11765038..11779128, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7590760..7604850, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lk6 kinase Neighboring gene long non-coding RNA:CR45595 Neighboring gene pruning defect 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis. Reddington JP, et al. Dev Cell, 2020 Dec 7. PMID 33171098
  2. Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics. Bravo González-Blas C, et al. Mol Syst Biol, 2020 May. PMID 32431014, Free PMC Article
  3. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Hoskins RA, et al. Genome Res, 2011 Feb. PMID 21177961, Free PMC Article
  4. NuRD-independent Mi-2 activity represses ectopic gene expression during neuronal maturation. Aughey GN, et al. EMBO Rep, 2023 Apr 5. PMID 36722816, Free PMC Article
  5. The GAGA factor regulatory network: Identification of GAGA factor associated proteins. Lomaev D, et al. PLoS One, 2017. PMID 28296955, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lethal (3) neo38
Names
CG6930-PA
CG6930-PB
CG6930-PC
CG6930-PD
CG6930-PF
CG6930-PG
CG6930-PI
CG6930-PJ
CG6930-PK
CG6930-PL
anon-fast-evolving-2F4
l(3)neo38-PA
l(3)neo38-PB
l(3)neo38-PC
l(3)neo38-PD
l(3)neo38-PF
l(3)neo38-PG
l(3)neo38-PI
l(3)neo38-PJ
l(3)neo38-PK
l(3)neo38-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11765038..11779128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043243.3 → NP_001036708.1  lethal (3) neo38, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSP5
    Conserved Domains (2) summary
    COG5048
    Location:341 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001260134.2 → NP_001247063.1  lethal (3) neo38, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6S1
    Conserved Domains (3) summary
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:219 → 304
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001260131.2 → NP_001247060.1  lethal (3) neo38, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6S1
    Conserved Domains (3) summary
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:219 → 304
    zf-C2H2_8; C2H2-type zinc ribbon

  4. NM_001260136.2 → NP_001247065.1  lethal (3) neo38, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247065.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R905
    Conserved Domains (2) summary
    COG5048
    Location:328 → 396
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001260133.2 → NP_001247062.1  lethal (3) neo38, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6F4
    Conserved Domains (2) summary
    COG5048
    Location:267 → 335
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001043244.3 → NP_001036709.1  lethal (3) neo38, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSP5
    Conserved Domains (2) summary
    COG5048
    Location:341 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001275556.2 → NP_001262485.1  lethal (3) neo38, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262485.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGA3
    Conserved Domains (3) summary
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:345 → 370
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:306 → 391
    zf-C2H2_8; C2H2-type zinc ribbon

  8. NM_001260135.1 → NP_001247064.1  lethal (3) neo38, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSP5
    Conserved Domains (2) summary
    COG5048
    Location:341 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001260130.1 → NP_001247059.1  lethal (3) neo38, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6F4
    Conserved Domains (2) summary
    COG5048
    Location:267 → 335
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_141856.3 → NP_650113.1  lethal (3) neo38, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650113.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZN9, Q9VGI3
    Related
    FBpp0082007
    Conserved Domains (3) summary
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:278 → 303
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:239 → 324
    zf-C2H2_8; C2H2-type zinc ribbon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6F4 A0A0B4K6F4
A0A0B4K6S1 A0A0B4K6S1
A0A0B4KGA3 A0A0B4KGA3
E0R905 E0R905
Q7KSP5 Q7KSP5
Q8MRX4 Q8MRX4
Q8SZN9 Q8SZN9

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