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Ugt35A1 UDP-glycosyltransferase family 35 member A1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41334, updated on 18-Sep-2024

Summary

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Official Symbol
Ugt35A1provided by FlyBase
Official Full Name
UDP-glycosyltransferase family 35 member A1provided by FlyBase
Primary source
FLYBASE:FBgn0026315
Locus tag
Dmel_CG6644
See related
AllianceGenome:FB:FBgn0026315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 006491F; CG6644; Dmel\CG6644; DmeUgt35a; UDPGT1; ugt35a; Ugt35a; UGT35A1; Ugt86Df
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; leg; and third segment of antenna. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ugt35A1 in Genome Data Viewer
Location:
86D5-86D5; 3-50 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11170817..11172664, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6996539..6998386, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 35 member E2 Neighboring gene UDP-glycosyltransferase family 35 member B1 Neighboring gene UDP-glycosyltransferase family 304 member A1 Neighboring gene UDP-glycosyltransferase family 303 member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preferential expression of biotransformation enzymes in the olfactory organs of Drosophila melanogaster, the antennae. Wang Q, et al. J Biol Chem, 1999 Apr 9. PMID 10187818
  2. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
  3. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
  4. Drosophila P elements preferentially transpose to replication origins. Spradling AC, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21896744, Free PMC Article
  5. Insect glycobiology: a lectin multigene family in Drosophila melanogaster. Theopold U, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441526

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glycosyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables UDP-glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycosylation ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
UDP-glycosyltransferase family 35 member A1
Names
CG6644-PA
UDP-glycosyltransferase 35a
Ugt35A1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11170817..11172664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079590.3 → NP_524314.2  UDP-glycosyltransferase family 35 member A1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524314.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGS9, Q9XYN4
    Related
    FBpp0081850
    Conserved Domains (2) summary
    PHA03392
    Location:19 → 474
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:55 → 526
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGS9 Q9VGS9
Q9XYN4 Q9XYN4

Gene LinkOut

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