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Mical Molecule interacting with CasL [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41225, updated on 22-Aug-2024

Summary

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Official Symbol
Micalprovided by FlyBase
Official Full Name
Molecule interacting with CasLprovided by FlyBase
Primary source
FLYBASE:FBgn0053208
Locus tag
Dmel_CG33208
See related
AllianceGenome:FB:FBgn0053208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11685; CG11687; CG18484; CG18667; CG18668; CG33186; CG33190; CG33208; Dmel\CG33208; mdcds_49226; mical; MICAL; milch
Summary
Enables FAD binding activity; actin binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Involved in several processes, including actin cytoskeleton organization; neuron development; and synapse assembly involved in innervation. Located in terminal bouton. Colocalizes with plasma membrane. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval muscle system; embryonic/larval neurons; germ layer derivative; and spermatozoon. Orthologous to several human genes including MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2) and MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Mical in Genome Data Viewer
Location:
85F5-85F7; 3-49 cM
Exon count:
28
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10001554..10042895, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5827276..5868617, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 85a Neighboring gene Serpin 85F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans. Wu H, et al. Sci Rep, 2018 Jan 17. PMID 29343822, Free PMC Article
  2. MICAL-like Regulates Fasciclin II Membrane Cycling and Synaptic Development. Nahm M, et al. Mol Cells, 2016 Oct. PMID 27770767, Free PMC Article
  3. Direct redox regulation of F-actin assembly and disassembly by Mical. Hung RJ, et al. Science, 2011 Dec 23. PMID 22116028, Free PMC Article
  4. F-actin dismantling through a redox-driven synergy between Mical and cofilin. Grintsevich EE, et al. Nat Cell Biol, 2016 Aug. PMID 27454820, Free PMC Article
  5. A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning. Kirilly D, et al. Nat Neurosci, 2009 Dec. PMID 19881505, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mical modulates Tau toxicity via cysteine oxidation in vivo.
    Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
  2. Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.
    Title: Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.
  3. Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
    Title: F-actin dismantling through a redox-driven synergy between Mical and cofilin.
  4. Results identify Mical-like as a novel regulator of synaptic growth and FasII endocytic recycling.
    Title: MICAL-like Regulates Fasciclin II Membrane Cycling and Synaptic Development.
  5. Mical oxidizes actin stereospecifically to generate actin Met-44-R-sulfoxide.
    Title: SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics.
  6. actin filament subunits were directly modified by Mical on their conserved pointed-end, critical for filament assembly; Mical posttranslationally oxidized the methionine 44 residue within D-loop of actin, severing filaments and decreasing polymerization
    Title: Direct redox regulation of F-actin assembly and disassembly by Mical.
  7. Mical is both necessary and sufficient for semaphorin-plexin-mediated F-actin reorganization in vivo
    Title: Mical links semaphorins to F-actin disassembly.
  8. a previously unknown pathway composed of Sox14 and its cytoskeletal target Mical governs dendrite severing during development
    Title: A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning.
  9. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
    Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
  10. Transgenic expression of interfering RNA molecules demonstrates that MICAL is required in muscles for the higher order arrangement of myofilaments.
    Title: Drosophila MICAL regulates myofilament organization and synaptic structure.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance TAS
Traceable Author Statement
more info
 PubMed 
involved_in dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly involved in innervation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
molecule interacting with CasL
Names
CG33208-PA
CG33208-PB
CG33208-PC
CG33208-PD
CG33208-PE
CG33208-PF
CG33208-PG
CG33208-PI
CG33208-PK
CG33208-PL
CG33208-PN
CG33208-PO
CG33208-PP
CG33208-PQ
Mical-PA
Mical-PB
Mical-PC
Mical-PD
Mical-PE
Mical-PF
Mical-PG
Mical-PI
Mical-PK
Mical-PL
Mical-PN
Mical-PO
Mical-PP
Mical-PQ
mical
milchstrasse
molecule that interacts with CasL
NP_001138032.1
NP_001247014.1
NP_001247015.1
NP_001247016.2
NP_001303502.1
NP_001303503.1
NP_788620.1
NP_788621.1
NP_788622.1
NP_788623.1
NP_788624.1
NP_788625.1
NP_788626.2
NP_788627.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10001554..10042895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260086.3 → NP_001247015.1  molecule interacting with CasL, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247015.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6D5
    Conserved Domains (5) summary
    pfam09528
    Location:2081 → 2479
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1097 → 1153
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4592 → 4705
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. NM_001260085.2 → NP_001247014.1  molecule interacting with CasL, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247014.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K703
    Conserved Domains (5) summary
    pfam09528
    Location:2081 → 2479
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1097 → 1153
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4581 → 4694
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  3. NM_176443.2 → NP_788620.1  molecule interacting with CasL, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BA1
    Related
    FBpp0081686
    Conserved Domains (4) summary
    cd09439
    Location:806 → 862
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:2583 → 2696
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  4. NM_001316574.1 → NP_001303503.1  molecule interacting with CasL, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUS6
    Conserved Domains (4) summary
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:2840 → 2953
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  5. NM_176444.2 → NP_788621.1  molecule interacting with CasL, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BA1
    Related
    FBpp0081685
    Conserved Domains (4) summary
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:2851 → 2964
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  6. NM_001260087.3 → NP_001247016.2  molecule interacting with CasL, isoform N [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6N6
    Conserved Domains (4) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  7. NM_001316573.1 → NP_001303502.1  molecule interacting with CasL, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUS4
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4538 → 4651
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  8. NM_176447.2 → NP_788624.1  molecule interacting with CasL, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788624.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0U5, F2FB99, Q86BA1, Q86BA2, Q86BA3, Q8MTA1, Q8MUJ8, Q8MUJ9, Q8MUK0, Q9VH41
    Related
    FBpp0081687
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4572 → 4685
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  9. NM_176445.2 → NP_788622.1  molecule interacting with CasL, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0U5, F2FB99, Q86BA1, Q86BA2, Q86BA3, Q8MTA1, Q8MUJ8, Q8MUJ9, Q8MUK0, Q9VH41
    Related
    FBpp0081688
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4572 → 4685
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  10. NM_176449.3 → NP_788626.2  molecule interacting with CasL, isoform O [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BA1
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4549 → 4662
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  11. NM_176448.2 → NP_788625.1  molecule interacting with CasL, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0U5, F2FB99, Q86BA1, Q86BA2, Q86BA3, Q8MTA1, Q8MUJ8, Q8MUJ9, Q8MUK0, Q9VH41
    Related
    FBpp0081690
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4572 → 4685
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  12. NM_176446.2 → NP_788623.1  molecule interacting with CasL, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0U5, F2FB99, Q86BA1, Q86BA2, Q86BA3, Q8MTA1, Q8MUJ8, Q8MUJ9, Q8MUK0, Q9VH41
    Related
    FBpp0081691
    Conserved Domains (5) summary
    pfam09528
    Location:2061 → 2459
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cd09439
    Location:1074 → 1130
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam12130
    Location:4572 → 4685
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  13. NM_176450.1 → NP_788627.1  molecule interacting with CasL, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BA1
    Related
    FBpp0081684, FBtr0082206
    Conserved Domains (3) summary
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    cl21454
    Location:131 → 255
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  14. NM_001144560.3 → NP_001138032.1  molecule interacting with CasL, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BA1
    Conserved Domains (3) summary
    cl00030
    Location:563 → 629
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl16912
    Location:114 → 160
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    cl21454
    Location:131 → 255
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6D5 A0A0B4K6D5
A0A0B4K6N6 A0A0B4K6N6
A0A0B4K703 A0A0B4K703
A0A126GUS4 A0A126GUS4
A0A126GUS6 A0A126GUS6
Q86BA1.1 Q86BA1

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