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Scm Sex comb on midleg [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41168, updated on 2-Nov-2024

Summary

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Official Symbol
Scmprovided by FlyBase
Official Full Name
Sex comb on midlegprovided by FlyBase
Primary source
FLYBASE:FBgn0003334
Locus tag
Dmel_CG9495
See related
AllianceGenome:FB:FBgn0003334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9495; Dmel\CG9495; l(3)85Ef; scm; SCM; Su(z)302
Summary
Enables PRC1 complex binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including axonogenesis; follicle cell of egg chamber development; and regulation of gene expression. Located in nucleus and polytene chromosome. Is expressed in several structures, including adult head; ganglia; ovary; and presumptive embryonic/larval central nervous system. Orthologous to human SCMH1 (Scm polycomb group protein homolog 1) and SCML2 (Scm polycomb group protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Scm in Genome Data Viewer
Location:
85E2-85E2; 3-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9633359..9637611, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5459081..5463333, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene stable intronic sequence RNA CR46357 Neighboring gene antisense RNA:CR45053 Neighboring gene Calreticulin Neighboring gene Spermidine Synthase Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Dynein heavy chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions. Peterson AJ, et al. Mol Cell Biol, 1997 Nov. PMID 9343432, Free PMC Article
  2. Activation of cytotoxic T lymphocytes in HLA-A, -B and -C-identical responder-stimulator pairs. I. Variations in generation of anti-class-II CTL in primary mixed lymphocyte cultures. Breuning MH, et al. Tissue Antigens, 1984 Aug. PMID 6238446
  3. Sex combs are important for male mating success in Drosophila melanogaster. Ng CS, et al. Behav Genet, 2008 Mar. PMID 18213513
  4. A genetic screen in Drosophila implicates Sex comb on midleg (Scm) in tissue overgrowth and mechanisms of Scm degradation by Wds. Guo J, et al. Mech Dev, 2015 May. PMID 25772304
  5. The non-proliferative nature of ascidian folliculogenesis as a model of highly ordered cellular topology distinct from proliferative epithelia. Azzag K, et al. PLoS One, 2015. PMID 26000769, Free PMC Article

See all (215) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
    Title: Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
  2. loss-of-function mutations in Scm result in non-autonomous tissue overgrowth in Drosophila, and determine that Scm is essential for ommatidium development and important for cell survival in Drosophila
    Title: A genetic screen in Drosophila implicates Sex comb on midleg (Scm) in tissue overgrowth and mechanisms of Scm degradation by Wds.
  3. Scm coordinates PcG complexes and polymerizes to produce broad domains of PcG silencing
    Title: Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila.
  4. SUMO negatively regulates Scm function by impeding its recruitment to the Ubx major PRE.
    Title: Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the polycomb group repressor Sex Comb on Midleg.
  5. Data show that Sex Comb on Midleg (SCM) associates with a Polycomb response element upstream of the Ubx gene which also binds PRC1, PRC2, and the DNA-binding PcG protein Pleiohomeotic.
    Title: Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene.
  6. Testing the role of this structure in male mating success in Drosophila melanogaster, the sex comb was removed by expressing the female-specific isoform of the sex determination gene transformer in the tarsal segments of male legs.
    Title: Sex combs are important for male mating success in Drosophila melanogaster.
  7. Data show that the MBT domain of Sex comb on midleg and its methyl-lysine-binding activity are required for repression of Hox genes.
    Title: Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg.
  8. polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression
    Title: Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer.
  9. SCM interacts and functions with Polycomb repressive complex 1 in gene silencing.
    Title: Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables PRC1 complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber stalk formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived female germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sex comb on midleg
Names
CG9495-PA
CG9495-PB
Scm-PA
Scm-PB
Sex comb on the midleg
Sex combs on midleg
Sex combs on midlegs
sex comb on midleg

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9633359..9637611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169299.2 → NP_731385.1  Sex comb on midleg, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24191, Q9VHA0
    UniProtKB/TrEMBL
    A0A0B4K6M7
    Related
    FBpp0081580
    Conserved Domains (5) summary
    cd09578
    Location:800 → 870
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:806 → 867
    SAM; Sterile alpha motif
    smart00561
    Location:178 → 273
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam06467
    Location:55 → 95
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12140
    Location:418 → 524
    DUF3588; Protein of unknown function (DUF3588)

  2. NM_001260077.2 → NP_001247006.1  Sex comb on midleg, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247006.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24191, Q9VHA0
    UniProtKB/TrEMBL
    A0A0B4K6M7
    Conserved Domains (5) summary
    cd09578
    Location:800 → 870
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:806 → 867
    SAM; Sterile alpha motif
    smart00561
    Location:178 → 273
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam06467
    Location:55 → 95
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12140
    Location:418 → 524
    DUF3588; Protein of unknown function (DUF3588)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6M7 A0A0B4K6M7
Q9VHA0.2 Q9VHA0

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