Calr Calreticulin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Calrprovided by FlyBase
Official Full Name: Calreticulinprovided by FlyBase
Primary source: FLYBASE:FBgn0005585
Locus tag: Dmel_CG9429
See related: AllianceGenome:FB:FBgn0005585
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe3D7; anon-EST:Liang-2.11; anon-EST:Liang-2.17; CALR; CG9429; chr3R:5454619..5454778; clone 2.11; clone 2.17; Clr; crc; Crc; CrT; Dmel\CG9429; eth; potp
Summary: Predicted to enable calcium ion binding activity. Involved in olfactory behavior and sleep. Located in extracellular space and fusome. Is expressed in several structures, including central nervous system; ectoderm; extended germ band embryo; presumptive embryonic/larval system; and ring gland. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to several human genes including CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9628691..9630851, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5454413..5456573, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed

Names: CG9429-PA; CG9429-PB; Calr-PA; Calr-PB; anon-fast-evolving-3D7; pot pourri; potpourri

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The following sections contain reference sequences that belong to a specific genome build. Explain