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Kap-alpha3 karyopherin alpha3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41158, updated on 2-Nov-2024

Summary

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Official Symbol
Kap-alpha3provided by FlyBase
Official Full Name
karyopherin alpha3provided by FlyBase
Primary source
FLYBASE:FBgn0027338
Locus tag
Dmel_CG9423
See related
AllianceGenome:FB:FBgn0027338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0335/13; alphaKap3; CG9423; Dalpha3; dimpalpha3; dKap-alpha3; Dmel\CG9423; Imp alpha-3; imp alpha3; Imp alpha3; imp-a3; imp-alpha3; Imp-alpha3; impalpha3; Impalpha3; IMPalpha3; Kap alpha3; Kap-?3; KAP-ALPHA3; Kapalpha3; kpn-alpha3; Kpn-alpha3; Kpna3; l(3)S033513
Summary
Enables Notch binding activity and myosin binding activity. Involved in protein import into nucleus and response to UV. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut; eye photoreceptor cell; and ganglia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Kap-alpha3 in Genome Data Viewer
Location:
85D25-85D25; 3-48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9574484..9577733, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5400206..5403455, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son RNA binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of karyopherin-alpha3 from Drosophila through its interaction with the nuclear localization sequence of germ cell-less protein. Dockendorff TC, et al. Biol Chem, 1999 Nov. PMID 10614818
  2. Identification of a classical bipartite nuclear localization signal in the Drosophila TEA/ATTS protein scalloped. Magico AC, et al. PLoS One, 2011. PMID 21731746, Free PMC Article
  3. Patterns of importin-alpha expression during Drosophila spermatogenesis. Giarrè M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490175
  4. Evolution of the metazoan-specific importin alpha gene family. Mason DA, et al. J Mol Evol, 2009 Apr. PMID 19308634
  5. Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Chamaon K, et al. J Neurochem, 2002 Jan. PMID 11796753

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A
    Title: DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6.
  2. These results reveal that the nuclear transport of Notch intracellular domain (Notch-ICD)is mediated by the canonical Importin-alpha3/Importin-beta transport pathway.
    Title: The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation.
  3. Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
    Title: Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.
  4. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
    Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
karyopherin alpha3
Names
CG9423-PA
CG9423-PB
CG9423-PC
CG9423-PD
Importin-alpha3
Kap-alpha3-PA
Kap-alpha3-PB
Kap-alpha3-PC
Kap-alpha3-PD
dImportin-alpha3
importin a3
importin alpha
importin alpha-3
importin alpha3
karyopherin
karyopherin a3
karyopherin alpha4
karyopherin-alpha3
karyopherin-alpha4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9574484..9577733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176437.2 → NP_788614.1  karyopherin alpha3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76522, Q9V455
    Related
    FBpp0081586
    Conserved Domains (5) summary
    COG5064
    Location:8 → 500
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:236 → 350
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:7 → 88
    IBB; Importin beta binding domain
    pfam16186
    Location:442 → 485
    Arm_3; Atypical Arm repeat
    sd00043
    Location:239 → 264
    ARM; armadillo repeat [structural motif]

  2. NM_169296.3 → NP_731378.1  karyopherin alpha3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76522, Q9V455
    Related
    FBpp0081585
    Conserved Domains (5) summary
    COG5064
    Location:8 → 500
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:236 → 350
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:7 → 88
    IBB; Importin beta binding domain
    pfam16186
    Location:442 → 485
    Arm_3; Atypical Arm repeat
    sd00043
    Location:239 → 264
    ARM; armadillo repeat [structural motif]

  3. NM_169295.3 → NP_731377.1  karyopherin alpha3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76522, Q9V455
    Related
    FBpp0081584
    Conserved Domains (5) summary
    COG5064
    Location:8 → 500
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:236 → 350
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:7 → 88
    IBB; Importin beta binding domain
    pfam16186
    Location:442 → 485
    Arm_3; Atypical Arm repeat
    sd00043
    Location:239 → 264
    ARM; armadillo repeat [structural motif]

  4. NM_001170101.1 → NP_001163572.1  karyopherin alpha3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76522, Q9V455
    Conserved Domains (5) summary
    COG5064
    Location:8 → 500
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:236 → 350
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:7 → 88
    IBB; Importin beta binding domain
    pfam16186
    Location:442 → 485
    Arm_3; Atypical Arm repeat
    sd00043
    Location:239 → 264
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76522 O76522
Q9UB78 Q9UB78
Q9V455 Q9V455

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