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MBD-like Methyl-CpG binding domain protein-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41151, updated on 2-Nov-2024

Summary

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Official Symbol
MBD-likeprovided by FlyBase
Official Full Name
Methyl-CpG binding domain protein-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0027950
Locus tag
Dmel_CG8208
See related
AllianceGenome:FB:FBgn0027950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8208; Dm Mbd2/3; dMBD-like; dMbD2/3; dMBD2/3; Dmel\CG8208; DmMbd2/3; MBD2; MBD2-3; MBD2/3; MBD3
Summary
Enables several functions, including histone deacetylase binding activity; methyl-CpG binding activity; and protein homodimerization activity. Involved in chromosome condensation and negative regulation of DNA-templated transcription. Located in nucleus and polytene chromosome. Part of NuRD complex. Is expressed in several structures, including gonad and male germline cell. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including MBD3 (methyl-CpG binding domain protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See MBD-like in Genome Data Viewer
Location:
85D24-85D24; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9559760..9561533)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5385482..5387255)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein S1 Neighboring gene uncharacterized protein Neighboring gene Branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene Adaptor Protein complex 1, mu subunit Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional repression by Drosophila methyl-CpG-binding proteins. Roder K, et al. Mol Cell Biol, 2000 Oct. PMID 10982856, Free PMC Article
  2. The effects of cadmium on the development of Drosophila and its transgenerational inheritance effects. Mu Y, et al. Toxicology, 2021 Oct. PMID 34508823
  3. DNA methylation learns to fly. Lyko F. Trends Genet, 2001 Apr. PMID 11275305
  4. Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Gupta T, et al. Sci Rep, 2017 Jul 14. PMID 28710457, Free PMC Article
  5. The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA. Marhold J, et al. Development, 2004 Dec. PMID 15537686

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that MBD-containing protein dMBD2/3 contribute to reproductive isolation and survival behavioral strategies.
    Title: Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila.
  2. results indicate that dMBD2/3 forms specialized nuclear compartments to keep certain genes epigenetically silenced during genome activation
    Title: Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables methyl-CpG binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Methyl-CpG binding domain protein-like
Names
CG8208-PA
CG8208-PB
CG8208-PC
MBD-like-PA
MBD-like-PB
MBD-like-PC
methyl-CpG-binding-domain-like-protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9559760..9561533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275492.1 → NP_001262421.1  Methyl-CpG binding domain protein-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGZ0
    Conserved Domains (3) summary
    pfam01429
    Location:13 → 98
    MBD; Methyl-CpG binding domain
    pfam14048
    Location:246 → 338
    MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
    pfam16564
    Location:172 → 241
    MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

  2. NM_169293.2 → NP_731370.1  Methyl-CpG binding domain protein-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731370.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHB7
    Related
    FBpp0081547
    Conserved Domains (3) summary
    pfam01429
    Location:13 → 97
    MBD; Methyl-CpG binding domain
    pfam14048
    Location:245 → 337
    MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
    pfam16564
    Location:171 → 240
    MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

  3. NM_141650.3 → NP_649907.1  Methyl-CpG binding domain protein-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V424
    Related
    FBpp0081546
    Conserved Domains (2) summary
    pfam14048
    Location:132 → 224
    MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
    pfam16564
    Location:58 → 127
    MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGZ0 A0A0B4KGZ0
Q9V424 Q9V424
Q9VHB7 Q9VHB7

Gene LinkOut

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