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alpha-Man-IIa alpha-Mannosidase class II a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41126, updated on 2-Nov-2024

Summary

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Official Symbol
alpha-Man-IIaprovided by FlyBase
Official Full Name
alpha-Mannosidase class II aprovided by FlyBase
Primary source
FLYBASE:FBgn0011740
Locus tag
Dmel_CG18802
See related
AllianceGenome:FB:FBgn0011740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
agr;-Man-II; alpha-Man-II; alpha-Man-IIA; alpha-Man-IIalpha; CG18474; CG18802; CG8139; dGMII; dGMIIb; DM-GII.1; Dmel\CG18802; GmII; GMII; Man; MAN-2; Man-II
Summary
Enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. Involved in N-glycan processing; encapsulation of foreign target; and rhodopsin biosynthetic process. Located in Golgi membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See alpha-Man-IIa in Genome Data Viewer
Location:
85D15-85D16; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9412548..9417264)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5238270..5242986)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 85D Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene pasilla Neighboring gene Glutathione S transferase Z1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Golgi α-mannosidase: opposing structures of Drosophila melanogaster and novel human model using molecular dynamics simulations and docking at different pHs. Drogalin A, et al. J Biomol Struct Dyn, 2024 Mar. PMID 37158092
  2. Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site. Shah N, et al. Proc Natl Acad Sci U S A, 2008 Jul 15. PMID 18599462, Free PMC Article
  3. The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Kuntz DA, et al. Chembiochem, 2009 Jan 26. PMID 19101978, Free PMC Article
  4. A long-wavelength fluorescent substrate for continuous fluorometric determination of alpha-mannosidase activity: resorufin alpha-D-mannopyranoside. Coleman DJ, et al. Anal Biochem, 2010 Apr 1. PMID 20026005, Free PMC Article
  5. Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II. Kuntz DA, et al. Chembiochem, 2010 Mar 22. PMID 20209559

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data show that the Drosophila metallophosphoesterase-dephosphorylated alpha-Man-II is required for the removal of the Rh1 oligosaccharide chain.
    Title: A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin.
  2. high-resolution crystal structure of a nucleophile mutant of Drosophila melanogaster GMII bound to its natural oligosaccharide substrate and an oligosaccharide precursor as well as the structure of the unliganded mutant.
    Title: Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.
  3. Drosophila melanogaster Golgi alpha-mannosidase II mechanism seen through the structural analysis of covalent reaction intermediates
    Title: Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rhodopsin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi stack NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
alpha-Mannosidase class II a
Names
CG18802-PA
CG18802-PB
alpha mannosidase II
alpha-Man-IIa-PA
alpha-Man-IIa-PB
alpha-mannosidase 2
alpha-mannosidase II
alpha-mannosidase-II
chain A, golgi Alpha-Mannosidase Ii
golgi Man II
golgi alpha-mannosidase
golgi alpha-mannosidase II
golgi mannosidase II
mannosidase II
NP_001262413.1
NP_524291.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9412548..9417264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275484.1 → NP_001262413.1  alpha-Mannosidase class II a, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262413.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFG0
    Conserved Domains (3) summary
    cd10809
    Location:144 → 483
    GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:478 → 554
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:744 → 1103
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

  2. NM_079567.3 → NP_524291.2  alpha-Mannosidase class II a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524291.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24451, Q9TYG5, Q9VHD8, Q9VHD9
    Related
    FBpp0081509
    Conserved Domains (3) summary
    cd10809
    Location:143 → 482
    GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:477 → 553
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:743 → 1102
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFG0 A0A0B4KFG0
Q24451.2 Q24451

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