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Kdm2 Lysine demethylase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41090, updated on 2-Nov-2024

Summary

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Official Symbol
Kdm2provided by FlyBase
Official Full Name
Lysine demethylase 2provided by FlyBase
Primary source
FLYBASE:FBgn0037659
Locus tag
Dmel_CG11033
See related
AllianceGenome:FB:FBgn0037659
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11033; dkdm2; dKdm2; dKDM2; Dmel\CG11033; dRAF1; FBXL19; JHDM1; kdm2; KDM2
Summary
Enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity. Involved in larval somatic muscle development and segment specification. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including adult pars intercerebralis; embryonic/larval epidermis; embryonic/larval salivary gland; gut section; and peritracheal cell. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Kdm2 in Genome Data Viewer
Location:
85C3-85C4; 3-48 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9052495..9063245)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4878217..4888967)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NAD-dependent methylenetetrahydrofolate dehydrogenase Neighboring gene Mst85C Neighboring gene Relish Neighboring gene beag Neighboring gene Adenosine deaminase Neighboring gene pumilio Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KDM2 Family Members are Regulated by HIF-1 in Hypoxia. Batie M, et al. Cells, 2017 Mar 17. PMID 28304334, Free PMC Article
  2. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Clissold PM, et al. Trends Biochem Sci, 2001 Jan. PMID 11165500
  3. Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species. Yu S, et al. Biochem Biophys Res Commun, 2015 Oct 2. PMID 26319556
  4. The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance. Nakajima E, et al. PLoS One, 2016. PMID 27907135, Free PMC Article
  5. Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization. Kavi HH, et al. BMC Res Notes, 2009 Oct 23. PMID 19852816, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in larval somatic muscle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in segment specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysine demethylase 2
Names
CG11033-PB
CG11033-PC
CG11033-PD
CG11033-PE
JmjC domain-containing histone demethylase 1
Kdm2-PB
Kdm2-PC
Kdm2-PD
Kdm2-PE
dRING-associated factor 1
lysine (K)-specific demethylase 2
NP_001262400.1
NP_001262401.1
NP_001262402.1
NP_649864.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9052495..9063245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141607.3 → NP_649864.2  lysine demethylase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649864.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU79, Q9VHH9
    UniProtKB/TrEMBL
    A0A0B4KFJ7, V5P0A0
    Conserved Domains (7) summary
    cd09293
    Location:1166 → 1320
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:670 → 716
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1126 → 1149
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1073 → 1108
    F-box-like; F-box-like
    pfam16866
    Location:721 → 801
    PHD_4; PHD-finger
    cl00309
    Location:394 → 467
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    cl21464
    Location:231 → 331
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_001275471.1 → NP_001262400.1  lysine demethylase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU79, Q9VHH9
    UniProtKB/TrEMBL
    A0A0B4KFJ7, V5P0A0
    Conserved Domains (7) summary
    cd09293
    Location:1166 → 1320
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:670 → 716
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1126 → 1149
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1073 → 1108
    F-box-like; F-box-like
    pfam16866
    Location:721 → 801
    PHD_4; PHD-finger
    cl00309
    Location:394 → 467
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    cl21464
    Location:231 → 331
    cupin_like; Conserved domain found in cupin and related proteins

  3. NM_001275473.1 → NP_001262402.1  lysine demethylase 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262402.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU79, Q9VHH9
    UniProtKB/TrEMBL
    A0A0B4KFJ7, V5P0A0
    Conserved Domains (7) summary
    cd09293
    Location:1166 → 1320
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:670 → 716
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1126 → 1149
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1073 → 1108
    F-box-like; F-box-like
    pfam16866
    Location:721 → 801
    PHD_4; PHD-finger
    cl00309
    Location:394 → 467
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    cl21464
    Location:231 → 331
    cupin_like; Conserved domain found in cupin and related proteins

  4. NM_001275472.1 → NP_001262401.1  lysine demethylase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262401.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU79, Q9VHH9
    UniProtKB/TrEMBL
    A0A0B4KFJ7, V5P0A0
    Conserved Domains (7) summary
    cd09293
    Location:1166 → 1320
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:670 → 716
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:1126 → 1149
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:1073 → 1108
    F-box-like; F-box-like
    pfam16866
    Location:721 → 801
    PHD_4; PHD-finger
    cl00309
    Location:394 → 467
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    cl21464
    Location:231 → 331
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFJ7 A0A0B4KFJ7
Q9VHH9.2 Q9VHH9

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