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hb hunchback [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41032, updated on 4-Jul-2024

Summary

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Official Symbol
hbprovided by FlyBase
Official Full Name
hunchbackprovided by FlyBase
Primary source
FLYBASE:FBgn0001180
Locus tag
Dmel_CG9786
See related
AllianceGenome:FB:FBgn0001180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9786; Dm-hb; Dm-Hb; Dmel\CG9786; Hb; HB; hbHLH; Hunchback; l(3)85Ah; R-pbx; Rg-bx; Rg-pbx
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of neural precursor cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ectoderm anlage; embryonic/larval nervous system; extended germ band embryo; germ layer; and somatic precursor cell. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
85A5-85A5; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8690980..8697822, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4516702..4523544, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44937 Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 216 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity. Torres-Oliva M, et al. PLoS Genet, 2018 Jan. PMID 29360820, Free PMC Article
  2. The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity. Hirono K, et al. Neural Dev, 2017 Jan 31. PMID 28137283, Free PMC Article
  3. Precision of Readout at the hunchback Gene: Analyzing Short Transcription Time Traces in Living Fly Embryos. Desponds J, et al. PLoS Comput Biol, 2016 Dec. PMID 27942043, Free PMC Article
  4. Sequential construction of a model for modular gene expression control, applied to spatial patterning of the Drosophila gene hunchback. Spirov AV, et al. J Bioinform Comput Biol, 2016 Apr. PMID 27122317
  5. MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding. Zellers RG, et al. BMC Bioinformatics, 2015 Jan 31. PMID 25637281, Free PMC Article

See all (1051) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
    Title: Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
  2. Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
    Title: Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
  3. Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
    Title: Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
  4. A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
    Title: A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
  5. Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
    Title: Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
  6. The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila
    Title: The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila.
  7. These data show Hb acts as a potent regulator of neuromuscular wiring decisions.
    Title: How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.
  8. Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
    Title: Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
  9. While Hunchback directly represses the eve stripe 3+7 enhancer, study found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression.
    Title: Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos.
  10. Hunchback (Hb) regulates a significant number of genes that are expressed during late differentiation stages. Hb is expressed in two polyploid subperineurial glia cells (carpet cells) and a thorough functional analysis shows that loss of Hb function results in a loss of carpet cells in the eye-antennal disc.
    Title: Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ganglion mother cell fate determination TAS
Traceable Author Statement
more info
 PubMed 
involved_in generation of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast fate determination IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuroblast fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in posterior head segmentation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of development, heterochronic TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in salivary gland development TAS
Traceable Author Statement
more info
 PubMed 
involved_in trunk segmentation TAS
Traceable Author Statement
more info
 PubMed 
involved_in ventral cord development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in zygotic determination of anterior/posterior axis, embryo NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in zygotic determination of anterior/posterior axis, embryo TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
hunchback
Names
CG9786-PA
CG9786-PB
Regulator-of-postbithorax
hb-PA
hb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8690980..8697822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169233.2 → NP_731267.1  hunchback, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731267.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05084, Q24018, Q29R06, Q960U7
    Related
    FBpp0081432
    Conserved Domains (3) summary
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:707 → 727
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:283 → 308
    zf-H2C2_2; Zinc-finger double domain

  2. NM_169234.2 → NP_731268.1  hunchback, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05084, Q24018, Q29R06, Q960U7
    Related
    FBpp0081431
    Conserved Domains (3) summary
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:707 → 727
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:283 → 308
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05084.2 P05084

Gene LinkOut

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