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CG10903 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40952, updated on 2-Nov-2024

Summary

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Official Symbol
CG10903provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037543
Locus tag
Dmel_CG10903
See related
AllianceGenome:FB:FBgn0037543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10903
Summary
Predicted to enable rRNA (guanine) methyltransferase activity. Predicted to be involved in rRNA (guanine-N7)-methylation. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG10903 in Genome Data Viewer
Location:
84E9-84E9; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8030411..8032145)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3856133..3857867)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene PSEA-binding protein 95kD Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncoordinated 45 Neighboring gene long non-coding RNA:CR44936

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article
  2. E2 ligase dRad6 regulates DMP53 turnover in Drosophila. Chen S, et al. J Biol Chem, 2011 Mar 18. PMID 21205821, Free PMC Article
  3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
  5. Identification of genetic suppressors of the Sin3A knockdown wing phenotype. Swaminathan A, et al. PLoS One, 2012. PMID 23166712, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (guanine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10903-PA
CG10903-PB
NP_001262365.1
NP_649762.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8030411..8032145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275436.1 → NP_001262365.1  uncharacterized protein Dmel_CG10903, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHW6
    Conserved Domains (2) summary
    pfam08241
    Location:56 → 142
    Methyltransf_11; Methyltransferase domain
    pfam12589
    Location:202 → 272
    WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome

  2. NM_141505.4 → NP_649762.1  uncharacterized protein Dmel_CG10903, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649762.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHW6
    Related
    FBpp0081283
    Conserved Domains (2) summary
    pfam08241
    Location:56 → 142
    Methyltransf_11; Methyltransferase domain
    pfam12589
    Location:202 → 272
    WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHW6 Q9VHW6

Gene LinkOut

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